Fatal glioblastoma after Gamma Knife radiosurgery for arteriovenous malformation in a child

Koichi Yoshida, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Hiroyuki Yanai, Keisuke Onoda, Isao Date

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We describe a fatal case of glioblastoma multiforme that was induced by Gamma Knife radiosurgery (GKS; Elekta AB, Stockholm, Sweden) for an arteriovenous malformation (AVM). A 4-year-old girl presented with repeated convulsions. Imaging studies revealed an AVM located in the right thalamus. One year after initial symptoms, GKS was performed to obliterate the nidus. The maximum and marginal radiation doses were 32 and 16 Gy, respectively. Seventy months after GKS, the patient represented with severe headache. MRI showed a poorly demarcated tumor with heterogeneous gadolinium enhancement in the right thalamus and adjacent to the white matter of the temporal lobe. After a generalised convulsion, the patient deteriorated into a deep coma. CT scans showed severe brain swelling with intratumoral hemorrhage. An emergency craniotomy was performed, and the hematoma was removed. During this surgery, a tumor mass, which was found adjacent to the hematoma, was resected. Microscopic examination revealed glioblastoma multiforme. Despite intensive treatment, the patient died 1 month after surgery. A GKS-induced secondary tumor is a rare but serious complication. It is important to be aware of the adverse effects of GKS, including secondary neoplasms, before its clinical application, especially in young patients.

Original languageEnglish
Pages (from-to)1453-1455
Number of pages3
JournalJournal of Clinical Neuroscience
Volume21
Issue number8
DOIs
Publication statusPublished - 2014

Fingerprint

Radiosurgery
Arteriovenous Malformations
Glioblastoma
Thalamus
Hematoma
Neoplasms
Seizures
Craniotomy
Brain Edema
Gadolinium
Temporal Lobe
Coma
Sweden
Headache
Emergencies
Radiation
Hemorrhage
Therapeutics

Keywords

  • Arteriovenous malformations
  • Gamma Knife radiosurgery
  • Glioblastoma multiforme
  • Radiation-induced neoplasms

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Medicine(all)

Cite this

Fatal glioblastoma after Gamma Knife radiosurgery for arteriovenous malformation in a child. / Yoshida, Koichi; Ichikawa, Tomotsugu; Kurozumi, Kazuhiko; Yanai, Hiroyuki; Onoda, Keisuke; Date, Isao.

In: Journal of Clinical Neuroscience, Vol. 21, No. 8, 2014, p. 1453-1455.

Research output: Contribution to journalArticle

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