Fast activity during EEG seizures in neonates

Lakshmi Nagarajan, Soumya Ghosh, Linda Palumbo, Tomoyuki Akiyama, Hiroshi Otsubo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: Paroxysmal fast activity (FA) has been proposed as a marker for epileptic networks. We explore the presence and significance of ictal FA on scalp video EEG seizures (EEG Sz) recorded in neonates. Methodology: Forty two babies had 159 EEG Szs. The seizures were analysed for ictal FA, using a low frequency filter of 30. Hz. We explored the relationship of ictal FA to the occurrence of electroclinical and electrographic seizures, the use of phenobarbitone and to neurodevelopmental outcomes. Results: Ictal FA occurred in 62 (39%) of the 159 EEG Szs. In the 62 seizures with ictal FA, 34 (55%) were electroclinical seizures (ECSz) and 28 (45%) were electrographic (ESz). In the remaining 97 seizures without ictal FA, 27 (28%) were ECSz and 70 (72%) ESz. There was a significant correlation (p= 0.0006) between ictal FA and electroclinical seizures. There was no relationship between phenobarbitone and presence of ictal FA. There was no significant difference in the background EEG, neuroimaging abnormalities, neurodevelopmental impairment or post neonatal seizures between those with and without ictal FA. Conclusions: Ictal FA is highly correlated to the occurrence of clinical features during an EEG seizure. The presence of ictal FA does not appear to influence neurodevelopmental outcomes.

Original languageEnglish
Pages (from-to)162-169
Number of pages8
JournalEpilepsy Research
Volume97
Issue number1-2
DOIs
Publication statusPublished - Nov 2011
Externally publishedYes

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Electroencephalography
Seizures
Stroke
Phenobarbital
Scalp
Neuroimaging

Keywords

  • Ictal fast activity
  • Neonatal seizures
  • Outcomes

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Nagarajan, L., Ghosh, S., Palumbo, L., Akiyama, T., & Otsubo, H. (2011). Fast activity during EEG seizures in neonates. Epilepsy Research, 97(1-2), 162-169. https://doi.org/10.1016/j.eplepsyres.2011.08.003

Fast activity during EEG seizures in neonates. / Nagarajan, Lakshmi; Ghosh, Soumya; Palumbo, Linda; Akiyama, Tomoyuki; Otsubo, Hiroshi.

In: Epilepsy Research, Vol. 97, No. 1-2, 11.2011, p. 162-169.

Research output: Contribution to journalArticle

Nagarajan, L, Ghosh, S, Palumbo, L, Akiyama, T & Otsubo, H 2011, 'Fast activity during EEG seizures in neonates', Epilepsy Research, vol. 97, no. 1-2, pp. 162-169. https://doi.org/10.1016/j.eplepsyres.2011.08.003
Nagarajan, Lakshmi ; Ghosh, Soumya ; Palumbo, Linda ; Akiyama, Tomoyuki ; Otsubo, Hiroshi. / Fast activity during EEG seizures in neonates. In: Epilepsy Research. 2011 ; Vol. 97, No. 1-2. pp. 162-169.
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