TY - JOUR
T1 - Fast (40–150 Hz) oscillations are associated with positive slow waves in the ictal EEGs of epileptic spasms in West syndrome
AU - Kobayashi, Katsuhiro
AU - Akiyama, Tomoyuki
AU - Oka, Makio
AU - Endoh, Fumika
AU - Yoshinaga, Harumi
N1 - Funding Information:
K. Kobayashi was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology , Japan (No. 24591513 and MEXT KAKENHI Grant Number 15H05874 [Non-linear Neuro-oscillology]) and by Health and Labour Research Grants from the Ministry of Health, Labour and Welfare , Japan. H. Yoshinaga was supported in part by the Japan Epilepsy Research Foundation .
Publisher Copyright:
© 2016 The Japanese Society of Child Neurology
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Objective To elucidate the generative mechanisms of epileptic spasms (ESs) in West syndrome, we investigated the temporal relationship between scalp fast (40–150 Hz) oscillations (FOs) and slow waves in the ictal electroencephalograms (EEGs) of ESs. Methods In 11 infants with WS, ictal FOs were detected in a bipolar montage based on spectral and waveform criteria. Their temporal distribution was analyzed in terms of the positive peaks (trough point, TT) of identical EEG data in a referential montage. Among six EEG data sections defined according to TT, the number of FOs, peak power values, and peak frequencies were compared. Results We identified a total of 1014 FOs (946 gamma and 68 ripple oscillations), which clustered closely at TT. The number of gamma oscillations in the 1 s epoch including TT was significantly higher than those in the prior and subsequent phases. Peak power values and frequencies tended to be higher in these positive phase sections. Conclusions The temporal association of FO clustering and positive slow waves in the ictal EEGs of ES indicated that active neuronal firing related to FOs underlies the generation of ESs and their ictal slow waves.
AB - Objective To elucidate the generative mechanisms of epileptic spasms (ESs) in West syndrome, we investigated the temporal relationship between scalp fast (40–150 Hz) oscillations (FOs) and slow waves in the ictal electroencephalograms (EEGs) of ESs. Methods In 11 infants with WS, ictal FOs were detected in a bipolar montage based on spectral and waveform criteria. Their temporal distribution was analyzed in terms of the positive peaks (trough point, TT) of identical EEG data in a referential montage. Among six EEG data sections defined according to TT, the number of FOs, peak power values, and peak frequencies were compared. Results We identified a total of 1014 FOs (946 gamma and 68 ripple oscillations), which clustered closely at TT. The number of gamma oscillations in the 1 s epoch including TT was significantly higher than those in the prior and subsequent phases. Peak power values and frequencies tended to be higher in these positive phase sections. Conclusions The temporal association of FO clustering and positive slow waves in the ictal EEGs of ES indicated that active neuronal firing related to FOs underlies the generation of ESs and their ictal slow waves.
KW - Fast oscillations
KW - High-frequency oscillations
KW - Ictal EEG
KW - Infantile spasms
KW - Slow wave
KW - West syndrome
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U2 - 10.1016/j.braindev.2016.05.005
DO - 10.1016/j.braindev.2016.05.005
M3 - Article
C2 - 27259671
AN - SCOPUS:84973528701
SN - 0387-7604
VL - 38
SP - 909
EP - 914
JO - Brain and Development
JF - Brain and Development
IS - 10
ER -