Fast (40-150Hz) oscillations are associated with positive slow waves in the ictal EEGs of epileptic spasms in West syndrome

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Abstract

Objective: To elucidate the generative mechanisms of epileptic spasms (ESs) in West syndrome, we investigated the temporal relationship between scalp fast (40-150. Hz) oscillations (FOs) and slow waves in the ictal electroencephalograms (EEGs) of ESs. Methods: In 11 infants with WS, ictal FOs were detected in a bipolar montage based on spectral and waveform criteria. Their temporal distribution was analyzed in terms of the positive peaks (trough point, TT) of identical EEG data in a referential montage. Among six EEG data sections defined according to TT, the number of FOs, peak power values, and peak frequencies were compared. Results: We identified a total of 1014 FOs (946 gamma and 68 ripple oscillations), which clustered closely at TT. The number of gamma oscillations in the 1s epoch including TT was significantly higher than those in the prior and subsequent phases. Peak power values and frequencies tended to be higher in these positive phase sections. Conclusions: The temporal association of FO clustering and positive slow waves in the ictal EEGs of ES indicated that active neuronal firing related to FOs underlies the generation of ESs and their ictal slow waves.

Original languageEnglish
JournalBrain and Development
DOIs
Publication statusAccepted/In press - Apr 26 2016

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Infantile Spasms
Spasm
Electroencephalography
Stroke
Scalp
Cluster Analysis

Keywords

  • Fast oscillations
  • High-frequency oscillations
  • Ictal EEG
  • Infantile spasms
  • Slow wave
  • West syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Pediatrics, Perinatology, and Child Health

Cite this

@article{89ffd317e66c48909b3512e269ca6a68,
title = "Fast (40-150Hz) oscillations are associated with positive slow waves in the ictal EEGs of epileptic spasms in West syndrome",
abstract = "Objective: To elucidate the generative mechanisms of epileptic spasms (ESs) in West syndrome, we investigated the temporal relationship between scalp fast (40-150. Hz) oscillations (FOs) and slow waves in the ictal electroencephalograms (EEGs) of ESs. Methods: In 11 infants with WS, ictal FOs were detected in a bipolar montage based on spectral and waveform criteria. Their temporal distribution was analyzed in terms of the positive peaks (trough point, TT) of identical EEG data in a referential montage. Among six EEG data sections defined according to TT, the number of FOs, peak power values, and peak frequencies were compared. Results: We identified a total of 1014 FOs (946 gamma and 68 ripple oscillations), which clustered closely at TT. The number of gamma oscillations in the 1s epoch including TT was significantly higher than those in the prior and subsequent phases. Peak power values and frequencies tended to be higher in these positive phase sections. Conclusions: The temporal association of FO clustering and positive slow waves in the ictal EEGs of ES indicated that active neuronal firing related to FOs underlies the generation of ESs and their ictal slow waves.",
keywords = "Fast oscillations, High-frequency oscillations, Ictal EEG, Infantile spasms, Slow wave, West syndrome",
author = "Katsuhiro Kobayashi and Tomoyuki Akiyama and Makio Oka and Fumika Endoh and Harumi Yoshinaga",
year = "2016",
month = "4",
day = "26",
doi = "10.1016/j.braindev.2016.05.005",
language = "English",
journal = "Brain and Development",
issn = "0387-7604",
publisher = "Elsevier",

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T1 - Fast (40-150Hz) oscillations are associated with positive slow waves in the ictal EEGs of epileptic spasms in West syndrome

AU - Kobayashi, Katsuhiro

AU - Akiyama, Tomoyuki

AU - Oka, Makio

AU - Endoh, Fumika

AU - Yoshinaga, Harumi

PY - 2016/4/26

Y1 - 2016/4/26

N2 - Objective: To elucidate the generative mechanisms of epileptic spasms (ESs) in West syndrome, we investigated the temporal relationship between scalp fast (40-150. Hz) oscillations (FOs) and slow waves in the ictal electroencephalograms (EEGs) of ESs. Methods: In 11 infants with WS, ictal FOs were detected in a bipolar montage based on spectral and waveform criteria. Their temporal distribution was analyzed in terms of the positive peaks (trough point, TT) of identical EEG data in a referential montage. Among six EEG data sections defined according to TT, the number of FOs, peak power values, and peak frequencies were compared. Results: We identified a total of 1014 FOs (946 gamma and 68 ripple oscillations), which clustered closely at TT. The number of gamma oscillations in the 1s epoch including TT was significantly higher than those in the prior and subsequent phases. Peak power values and frequencies tended to be higher in these positive phase sections. Conclusions: The temporal association of FO clustering and positive slow waves in the ictal EEGs of ES indicated that active neuronal firing related to FOs underlies the generation of ESs and their ictal slow waves.

AB - Objective: To elucidate the generative mechanisms of epileptic spasms (ESs) in West syndrome, we investigated the temporal relationship between scalp fast (40-150. Hz) oscillations (FOs) and slow waves in the ictal electroencephalograms (EEGs) of ESs. Methods: In 11 infants with WS, ictal FOs were detected in a bipolar montage based on spectral and waveform criteria. Their temporal distribution was analyzed in terms of the positive peaks (trough point, TT) of identical EEG data in a referential montage. Among six EEG data sections defined according to TT, the number of FOs, peak power values, and peak frequencies were compared. Results: We identified a total of 1014 FOs (946 gamma and 68 ripple oscillations), which clustered closely at TT. The number of gamma oscillations in the 1s epoch including TT was significantly higher than those in the prior and subsequent phases. Peak power values and frequencies tended to be higher in these positive phase sections. Conclusions: The temporal association of FO clustering and positive slow waves in the ictal EEGs of ES indicated that active neuronal firing related to FOs underlies the generation of ESs and their ictal slow waves.

KW - Fast oscillations

KW - High-frequency oscillations

KW - Ictal EEG

KW - Infantile spasms

KW - Slow wave

KW - West syndrome

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