Familial interstitial nephritis with progressive renal failure.

H. Zhang, Jun Wada, K. Nanba, M. Kunitomi, K. Hida, Y. Nagake, Kenichi Shikata, Hirofumi Makino

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We describe a 53-year-old woman with chronic interstitial nephritis and asymptomatic impairment of renal function. Seven members of her family were suffering from renal failure and underwent hemodialysis. At the time of their hospital admissions, they had shown evidence of end-stage renal failure at 40 to 50 years of age. Lack of proteinuria, hematuria, hypertension, hyperuricemia, hearing loss, and visual impairment were present before the deterioration of the renal function. Renal biopsy of the presented case indicated chronic interstitial nephritis without glomerular basement membrane abnormalities. Progressive decline of renal function and the inheritance pattern of autosomal dominance in this family suggested the diagnosis of familial interstitial nephritis.

Original languageEnglish
JournalAmerican Journal of Kidney Diseases
Volume36
Issue number4
Publication statusPublished - 2000

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Hereditary Nephritis
Interstitial Nephritis
Renal Insufficiency
Kidney
Hearing Loss
Inheritance Patterns
Hyperuricemia
Glomerular Basement Membrane
Vision Disorders
Hematuria
Proteinuria
Chronic Kidney Failure
Renal Dialysis
Hypertension
Biopsy

Cite this

Familial interstitial nephritis with progressive renal failure. / Zhang, H.; Wada, Jun; Nanba, K.; Kunitomi, M.; Hida, K.; Nagake, Y.; Shikata, Kenichi; Makino, Hirofumi.

In: American Journal of Kidney Diseases, Vol. 36, No. 4, 2000.

Research output: Contribution to journalArticle

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AU - Zhang, H.

AU - Wada, Jun

AU - Nanba, K.

AU - Kunitomi, M.

AU - Hida, K.

AU - Nagake, Y.

AU - Shikata, Kenichi

AU - Makino, Hirofumi

PY - 2000

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AB - We describe a 53-year-old woman with chronic interstitial nephritis and asymptomatic impairment of renal function. Seven members of her family were suffering from renal failure and underwent hemodialysis. At the time of their hospital admissions, they had shown evidence of end-stage renal failure at 40 to 50 years of age. Lack of proteinuria, hematuria, hypertension, hyperuricemia, hearing loss, and visual impairment were present before the deterioration of the renal function. Renal biopsy of the presented case indicated chronic interstitial nephritis without glomerular basement membrane abnormalities. Progressive decline of renal function and the inheritance pattern of autosomal dominance in this family suggested the diagnosis of familial interstitial nephritis.

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