Factors that influence primary cilium length

Ko Miyoshi, Kyosuke Kasahara, Ikuko Miyazaki, Masato Asanuma

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies. Recent studies have demonstrated that some pharmacological agents and extracellular environmental changes can alter primary cilium length. Renal injury is a well-known example of an environmental insult that triggers cilia length modification. Lithium treatment causes primary cilia to extend in several cell types including neuronal cells; this phenomenon is likely independent of glycogen synthase kinase-3/β inhibition. In renal epithelial cell lines, deflection of the primary cilia by fluid shear shortens them by reducing the intracellular cyclic AMP level, leading to a subsequent decrease in mechanosensitivity to fluid shear. Primary cilium length is also influenced by the dynamics of actin filaments and microtubules through the levels of soluble tubulin in the cytosol available for primary cilia extension. Thus, mammalian cells can adapt to the extracellular environment by modulating the primary cilium length, and this feedback system utilizing primary cilia might exist throughout the mammalian body. Further investigation is required concerning the precise molecular mechanisms underlying the control of primary cilium length in response to environmental factors.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalActa Medica Okayama
Volume65
Issue number5
Publication statusPublished - 2011

Fingerprint

Cilia
Cells
Glycogen Synthase Kinase 3
Fluids
Tubulin
Lithium
Biosensors
Cyclic AMP
Actins
Feedback
Kidney
Biosensing Techniques
Actin Cytoskeleton
Microtubules
Cytosol
Epithelial Cells
Pharmacology
Cell Line

Keywords

  • Cyclic AMP
  • Intraflagellar transport
  • Lithium
  • Primary cilium length
  • Soluble tubulin

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Factors that influence primary cilium length. / Miyoshi, Ko; Kasahara, Kyosuke; Miyazaki, Ikuko; Asanuma, Masato.

In: Acta Medica Okayama, Vol. 65, No. 5, 2011, p. 279-285.

Research output: Contribution to journalArticle

Miyoshi, K, Kasahara, K, Miyazaki, I & Asanuma, M 2011, 'Factors that influence primary cilium length', Acta Medica Okayama, vol. 65, no. 5, pp. 279-285.
Miyoshi, Ko ; Kasahara, Kyosuke ; Miyazaki, Ikuko ; Asanuma, Masato. / Factors that influence primary cilium length. In: Acta Medica Okayama. 2011 ; Vol. 65, No. 5. pp. 279-285.
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