Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy

Yasuhito Wakasaya, Takeshi Kawarabayashi, Mitsunori Watanabe, Yukiko Yamamoto-Watanabe, Ayumi Takamura, Tomoko Kurata, Tetsuro Murakami, Koji Abe, Kiyofumi Yamada, Koichi Wakabayashi, Atsushi Sasaki, David Westaway, Peter St George Hyslop, Etsuro Matsubara, Mikio Shoji

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

TgTauP301L mice that overexpress the mutant human tauP301L present in FTDP-17 reproduce neurofibrillary tangles (NFTs), neuronal cell losses, memory disturbance, and substantial phenotypic variation. To demonstrate factors responsible for NFT formation and neuronal cell losses, sets of TgTauP301L for comparison with or without NFTs and neuronal cell losses were studied with oligonucleotide microarrays. Gene expressions were altered in biological pathways, including oxidative stress, apoptosis, mitochondrial fatty acid betaoxidation, inflammatory response pathway, and complement and coagulation cascade pathways. Among 24 altered genes, increased levels of apolipoprotein D (ApoD) and neuronal PAS domain protein 4 (Npas4) and decreased levels of doublecortin (DCX) and potassium channel, voltage-gated, shaker-related subfamily, β member 1 (Kcnab1) were found in the TgTauP301L with NFTs and neuronal cell losses, Alzheimer's brains, and tauopathy brains. Thus, many biological pathways and novel molecules are associated with NFT formation and neuronal cell losses in tauopathy brains.

Original languageEnglish
Pages (from-to)576-584
Number of pages9
JournalJournal of Neuroscience Research
Volume89
Issue number4
DOIs
Publication statusPublished - Apr 1 2011

Keywords

  • Apo D
  • DCX
  • Kcnab1
  • Npas4
  • Tauopathy

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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    Wakasaya, Y., Kawarabayashi, T., Watanabe, M., Yamamoto-Watanabe, Y., Takamura, A., Kurata, T., Murakami, T., Abe, K., Yamada, K., Wakabayashi, K., Sasaki, A., Westaway, D., Hyslop, P. S. G., Matsubara, E., & Shoji, M. (2011). Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy. Journal of Neuroscience Research, 89(4), 576-584. https://doi.org/10.1002/jnr.22572