Abstract
Purpose To quantify the vascular density of the choroid of normal eyes and to identify the influencing factors using en face images obtained with swept-source optical coherence tomography (SS OCT). Design Prospective cross-sectional study. Methods One hundred and sixty-three eyes of 163 healthy volunteers (83 female; mean age 42.2 ± 22.6 years) with a corrected visual acuity of ≥1.0 were investigated. En face SS OCT images of the choroid were used for quantitative assessment of the vascular density in the large choroid vessel layer. Relationships between vascular density of the choroid and age, sex, refractive error (RE), axial length (AL), and subfoveal choroidal thickness (SCT) were also investigated. Results There was a significant negative relationship between vascular density of the choroid and subject age (P <.001). Analysis according to age showed a significant correlation in the group aged >30 years (P <.001), but not in the group aged ≤30 years (P =.225). SCT had a significant positive relationship with vascular density of the choroid (P <.001). However, a significant correlation was not observed between sex, RE, or AL and vascular density of the choroid (P =.981, P =.292, and P =.216, respectively). Multivariable regression analysis with vascular density of the choroid as the dependent variable and age, sex, RE, AL, and SCT as independent variables showed that age and SCT are important determinants of vascular density of the choroid (P <.001). Conclusion Age and SCT affect vascular density of the choroid.
| Original language | English |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | American Journal of Ophthalmology |
| Volume | 170 |
| DOIs | |
| Publication status | Published - Oct 1 2016 |
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ASJC Scopus subject areas
- Medicine(all)
- Ophthalmology
Cite this
Factors Affecting Choroidal Vascular Density in Normal Eyes : Quantification Using En Face Swept-Source Optical Coherence Tomography. / Fujiwara, Atsushi; Morizane, Yuki; Hosokawa, Mio; Kimura, Shuhei; Kumase, Fumiaki; Shiode, Yusuke; Doi, Shinichiro; Hirano, Masayuki; Toshima, Shinji; Hosogi, Mika; Shiraga, Fumio.
In: American Journal of Ophthalmology, Vol. 170, 01.10.2016, p. 1-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Factors Affecting Choroidal Vascular Density in Normal Eyes
T2 - Quantification Using En Face Swept-Source Optical Coherence Tomography
AU - Fujiwara, Atsushi
AU - Morizane, Yuki
AU - Hosokawa, Mio
AU - Kimura, Shuhei
AU - Kumase, Fumiaki
AU - Shiode, Yusuke
AU - Doi, Shinichiro
AU - Hirano, Masayuki
AU - Toshima, Shinji
AU - Hosogi, Mika
AU - Shiraga, Fumio
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Purpose To quantify the vascular density of the choroid of normal eyes and to identify the influencing factors using en face images obtained with swept-source optical coherence tomography (SS OCT). Design Prospective cross-sectional study. Methods One hundred and sixty-three eyes of 163 healthy volunteers (83 female; mean age 42.2 ± 22.6 years) with a corrected visual acuity of ≥1.0 were investigated. En face SS OCT images of the choroid were used for quantitative assessment of the vascular density in the large choroid vessel layer. Relationships between vascular density of the choroid and age, sex, refractive error (RE), axial length (AL), and subfoveal choroidal thickness (SCT) were also investigated. Results There was a significant negative relationship between vascular density of the choroid and subject age (P <.001). Analysis according to age showed a significant correlation in the group aged >30 years (P <.001), but not in the group aged ≤30 years (P =.225). SCT had a significant positive relationship with vascular density of the choroid (P <.001). However, a significant correlation was not observed between sex, RE, or AL and vascular density of the choroid (P =.981, P =.292, and P =.216, respectively). Multivariable regression analysis with vascular density of the choroid as the dependent variable and age, sex, RE, AL, and SCT as independent variables showed that age and SCT are important determinants of vascular density of the choroid (P <.001). Conclusion Age and SCT affect vascular density of the choroid.
AB - Purpose To quantify the vascular density of the choroid of normal eyes and to identify the influencing factors using en face images obtained with swept-source optical coherence tomography (SS OCT). Design Prospective cross-sectional study. Methods One hundred and sixty-three eyes of 163 healthy volunteers (83 female; mean age 42.2 ± 22.6 years) with a corrected visual acuity of ≥1.0 were investigated. En face SS OCT images of the choroid were used for quantitative assessment of the vascular density in the large choroid vessel layer. Relationships between vascular density of the choroid and age, sex, refractive error (RE), axial length (AL), and subfoveal choroidal thickness (SCT) were also investigated. Results There was a significant negative relationship between vascular density of the choroid and subject age (P <.001). Analysis according to age showed a significant correlation in the group aged >30 years (P <.001), but not in the group aged ≤30 years (P =.225). SCT had a significant positive relationship with vascular density of the choroid (P <.001). However, a significant correlation was not observed between sex, RE, or AL and vascular density of the choroid (P =.981, P =.292, and P =.216, respectively). Multivariable regression analysis with vascular density of the choroid as the dependent variable and age, sex, RE, AL, and SCT as independent variables showed that age and SCT are important determinants of vascular density of the choroid (P <.001). Conclusion Age and SCT affect vascular density of the choroid.
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U2 - 10.1016/j.ajo.2016.07.006
DO - 10.1016/j.ajo.2016.07.006
M3 - Article
C2 - 27430684
AN - SCOPUS:84983483187
VL - 170
SP - 1
EP - 9
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
ER -