Abstract
The past several years have seen an explosive growth in the application of recombinant DNA methods to study the molecular pathology of various inherited disorders. As a consequence, molecular defects responsible for the disease have been identified at the sequence level. In this review, I briefly describe the recent progress in the uses of factor IX gene probes in clinical diagnosis of hemophilia B (Christmas disease) carriers, as well as their use for analyzing the structural gene abnormalities that are responsible for the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 811-815 |
| Number of pages | 5 |
| Journal | Acta Haematologica Japonica |
| Volume | 52 |
| Issue number | 4 |
| Publication status | Published - Jul 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Hematology
Cite this
Factor IX molecular defects in diagnosing hemophilia B : a review. / Tanimoto, M.
In: Acta Haematologica Japonica, Vol. 52, No. 4, 07.1989, p. 811-815.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Factor IX molecular defects in diagnosing hemophilia B
T2 - a review.
AU - Tanimoto, M.
PY - 1989/7
Y1 - 1989/7
N2 - The past several years have seen an explosive growth in the application of recombinant DNA methods to study the molecular pathology of various inherited disorders. As a consequence, molecular defects responsible for the disease have been identified at the sequence level. In this review, I briefly describe the recent progress in the uses of factor IX gene probes in clinical diagnosis of hemophilia B (Christmas disease) carriers, as well as their use for analyzing the structural gene abnormalities that are responsible for the disease.
AB - The past several years have seen an explosive growth in the application of recombinant DNA methods to study the molecular pathology of various inherited disorders. As a consequence, molecular defects responsible for the disease have been identified at the sequence level. In this review, I briefly describe the recent progress in the uses of factor IX gene probes in clinical diagnosis of hemophilia B (Christmas disease) carriers, as well as their use for analyzing the structural gene abnormalities that are responsible for the disease.
UR - http://www.scopus.com/inward/record.url?scp=0024690195&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024690195&partnerID=8YFLogxK
M3 - Article
C2 - 2694721
AN - SCOPUS:0024690195
VL - 52
SP - 811
EP - 815
JO - International Journal of Hematology
JF - International Journal of Hematology
SN - 0925-5710
IS - 4
ER -