Abstract
The effects of the portal infusion of hyper- and hypotonic solution on gastric motility in rats were investigated. The infusion of hypertonic saline into the portal vein (portal infusion) elicited a significant enhancement of gastric contractile activity. The portal infusion of water also produced this enhancement. However, the portal infusion of isotonic saline showed no significant enhancement; nor did the infusion of water and hypertonic saline into the jugular vein. Sectioning of the hepatic branch of the vagus nerve (hepatic vagus) eliminated the enhanced responses of the gastric motility. It is therefore concluded that hepatoportal osmoreceptive afferent signals affect the gastric motility by way of the hepatic vagus. These effects on osmolarity revealed that hypotonic stimulation is more effective than hypertonic stimulation for the enhancement of motility. Sectioning of the dorsal subdiaphragmatic vagus, which includes the dorsal gastric and celiac branch, did not eliminate these responses. Sectioning of the ventral gastric vagus, in contrast, did eliminate the responses. These results suggest that vagal preganglionic neurons in the left dorsal motor nucleus of the vagus play a role in enhancement of gastric motility observed in the present research. Copyright (C) 1998 Elsevier Science B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 156-162 |
| Number of pages | 7 |
| Journal | Journal of the Autonomic Nervous System |
| Volume | 73 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - Nov 10 1998 |
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Keywords
- Gastric motility
- Hepatic
- Osmoreceptor
- Portal
- Stomach
- Vagal nerve
ASJC Scopus subject areas
- Physiology
- Clinical Neurology
- Neuroscience(all)
Cite this
Facilitation of gastric motility induced by portal infusion of hyper- and hypotonic solution in rats. / Kobashi, Motoi; Mizutani, Masatoshi; Adachi, Akira.
In: Journal of the Autonomic Nervous System, Vol. 73, No. 2-3, 10.11.1998, p. 156-162.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Facilitation of gastric motility induced by portal infusion of hyper- and hypotonic solution in rats
AU - Kobashi, Motoi
AU - Mizutani, Masatoshi
AU - Adachi, Akira
PY - 1998/11/10
Y1 - 1998/11/10
N2 - The effects of the portal infusion of hyper- and hypotonic solution on gastric motility in rats were investigated. The infusion of hypertonic saline into the portal vein (portal infusion) elicited a significant enhancement of gastric contractile activity. The portal infusion of water also produced this enhancement. However, the portal infusion of isotonic saline showed no significant enhancement; nor did the infusion of water and hypertonic saline into the jugular vein. Sectioning of the hepatic branch of the vagus nerve (hepatic vagus) eliminated the enhanced responses of the gastric motility. It is therefore concluded that hepatoportal osmoreceptive afferent signals affect the gastric motility by way of the hepatic vagus. These effects on osmolarity revealed that hypotonic stimulation is more effective than hypertonic stimulation for the enhancement of motility. Sectioning of the dorsal subdiaphragmatic vagus, which includes the dorsal gastric and celiac branch, did not eliminate these responses. Sectioning of the ventral gastric vagus, in contrast, did eliminate the responses. These results suggest that vagal preganglionic neurons in the left dorsal motor nucleus of the vagus play a role in enhancement of gastric motility observed in the present research. Copyright (C) 1998 Elsevier Science B.V.
AB - The effects of the portal infusion of hyper- and hypotonic solution on gastric motility in rats were investigated. The infusion of hypertonic saline into the portal vein (portal infusion) elicited a significant enhancement of gastric contractile activity. The portal infusion of water also produced this enhancement. However, the portal infusion of isotonic saline showed no significant enhancement; nor did the infusion of water and hypertonic saline into the jugular vein. Sectioning of the hepatic branch of the vagus nerve (hepatic vagus) eliminated the enhanced responses of the gastric motility. It is therefore concluded that hepatoportal osmoreceptive afferent signals affect the gastric motility by way of the hepatic vagus. These effects on osmolarity revealed that hypotonic stimulation is more effective than hypertonic stimulation for the enhancement of motility. Sectioning of the dorsal subdiaphragmatic vagus, which includes the dorsal gastric and celiac branch, did not eliminate these responses. Sectioning of the ventral gastric vagus, in contrast, did eliminate the responses. These results suggest that vagal preganglionic neurons in the left dorsal motor nucleus of the vagus play a role in enhancement of gastric motility observed in the present research. Copyright (C) 1998 Elsevier Science B.V.
KW - Gastric motility
KW - Hepatic
KW - Osmoreceptor
KW - Portal
KW - Stomach
KW - Vagal nerve
UR - http://www.scopus.com/inward/record.url?scp=0031736833&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031736833&partnerID=8YFLogxK
U2 - 10.1016/S0165-1838(98)00138-6
DO - 10.1016/S0165-1838(98)00138-6
M3 - Article
C2 - 9862391
AN - SCOPUS:0031736833
VL - 73
SP - 156
EP - 162
JO - Autonomic Neuroscience: Basic and Clinical
JF - Autonomic Neuroscience: Basic and Clinical
SN - 1566-0702
IS - 2-3
ER -