Facilitation of gastric motility induced by portal infusion of hyper- and hypotonic solution in rats

Motoi Kobashi, Masatoshi Mizutani, Akira Adachi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effects of the portal infusion of hyper- and hypotonic solution on gastric motility in rats were investigated. The infusion of hypertonic saline into the portal vein (portal infusion) elicited a significant enhancement of gastric contractile activity. The portal infusion of water also produced this enhancement. However, the portal infusion of isotonic saline showed no significant enhancement; nor did the infusion of water and hypertonic saline into the jugular vein. Sectioning of the hepatic branch of the vagus nerve (hepatic vagus) eliminated the enhanced responses of the gastric motility. It is therefore concluded that hepatoportal osmoreceptive afferent signals affect the gastric motility by way of the hepatic vagus. These effects on osmolarity revealed that hypotonic stimulation is more effective than hypertonic stimulation for the enhancement of motility. Sectioning of the dorsal subdiaphragmatic vagus, which includes the dorsal gastric and celiac branch, did not eliminate these responses. Sectioning of the ventral gastric vagus, in contrast, did eliminate the responses. These results suggest that vagal preganglionic neurons in the left dorsal motor nucleus of the vagus play a role in enhancement of gastric motility observed in the present research. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalJournal of the Autonomic Nervous System
Volume73
Issue number2-3
DOIs
Publication statusPublished - Nov 10 1998

Fingerprint

Hypotonic Solutions
Hypertonic Solutions
Stomach
Liver
Vagus Nerve
Jugular Veins
Portal Vein
Abdomen
Osmolar Concentration
Neurons
Water

Keywords

  • Gastric motility
  • Hepatic
  • Osmoreceptor
  • Portal
  • Stomach
  • Vagal nerve

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Facilitation of gastric motility induced by portal infusion of hyper- and hypotonic solution in rats. / Kobashi, Motoi; Mizutani, Masatoshi; Adachi, Akira.

In: Journal of the Autonomic Nervous System, Vol. 73, No. 2-3, 10.11.1998, p. 156-162.

Research output: Contribution to journalArticle

@article{ea115e40b0c84a70ab36e48f789f70df,
title = "Facilitation of gastric motility induced by portal infusion of hyper- and hypotonic solution in rats",
abstract = "The effects of the portal infusion of hyper- and hypotonic solution on gastric motility in rats were investigated. The infusion of hypertonic saline into the portal vein (portal infusion) elicited a significant enhancement of gastric contractile activity. The portal infusion of water also produced this enhancement. However, the portal infusion of isotonic saline showed no significant enhancement; nor did the infusion of water and hypertonic saline into the jugular vein. Sectioning of the hepatic branch of the vagus nerve (hepatic vagus) eliminated the enhanced responses of the gastric motility. It is therefore concluded that hepatoportal osmoreceptive afferent signals affect the gastric motility by way of the hepatic vagus. These effects on osmolarity revealed that hypotonic stimulation is more effective than hypertonic stimulation for the enhancement of motility. Sectioning of the dorsal subdiaphragmatic vagus, which includes the dorsal gastric and celiac branch, did not eliminate these responses. Sectioning of the ventral gastric vagus, in contrast, did eliminate the responses. These results suggest that vagal preganglionic neurons in the left dorsal motor nucleus of the vagus play a role in enhancement of gastric motility observed in the present research. Copyright (C) 1998 Elsevier Science B.V.",
keywords = "Gastric motility, Hepatic, Osmoreceptor, Portal, Stomach, Vagal nerve",
author = "Motoi Kobashi and Masatoshi Mizutani and Akira Adachi",
year = "1998",
month = "11",
day = "10",
doi = "10.1016/S0165-1838(98)00138-6",
language = "English",
volume = "73",
pages = "156--162",
journal = "Autonomic Neuroscience: Basic and Clinical",
issn = "1566-0702",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - Facilitation of gastric motility induced by portal infusion of hyper- and hypotonic solution in rats

AU - Kobashi, Motoi

AU - Mizutani, Masatoshi

AU - Adachi, Akira

PY - 1998/11/10

Y1 - 1998/11/10

N2 - The effects of the portal infusion of hyper- and hypotonic solution on gastric motility in rats were investigated. The infusion of hypertonic saline into the portal vein (portal infusion) elicited a significant enhancement of gastric contractile activity. The portal infusion of water also produced this enhancement. However, the portal infusion of isotonic saline showed no significant enhancement; nor did the infusion of water and hypertonic saline into the jugular vein. Sectioning of the hepatic branch of the vagus nerve (hepatic vagus) eliminated the enhanced responses of the gastric motility. It is therefore concluded that hepatoportal osmoreceptive afferent signals affect the gastric motility by way of the hepatic vagus. These effects on osmolarity revealed that hypotonic stimulation is more effective than hypertonic stimulation for the enhancement of motility. Sectioning of the dorsal subdiaphragmatic vagus, which includes the dorsal gastric and celiac branch, did not eliminate these responses. Sectioning of the ventral gastric vagus, in contrast, did eliminate the responses. These results suggest that vagal preganglionic neurons in the left dorsal motor nucleus of the vagus play a role in enhancement of gastric motility observed in the present research. Copyright (C) 1998 Elsevier Science B.V.

AB - The effects of the portal infusion of hyper- and hypotonic solution on gastric motility in rats were investigated. The infusion of hypertonic saline into the portal vein (portal infusion) elicited a significant enhancement of gastric contractile activity. The portal infusion of water also produced this enhancement. However, the portal infusion of isotonic saline showed no significant enhancement; nor did the infusion of water and hypertonic saline into the jugular vein. Sectioning of the hepatic branch of the vagus nerve (hepatic vagus) eliminated the enhanced responses of the gastric motility. It is therefore concluded that hepatoportal osmoreceptive afferent signals affect the gastric motility by way of the hepatic vagus. These effects on osmolarity revealed that hypotonic stimulation is more effective than hypertonic stimulation for the enhancement of motility. Sectioning of the dorsal subdiaphragmatic vagus, which includes the dorsal gastric and celiac branch, did not eliminate these responses. Sectioning of the ventral gastric vagus, in contrast, did eliminate the responses. These results suggest that vagal preganglionic neurons in the left dorsal motor nucleus of the vagus play a role in enhancement of gastric motility observed in the present research. Copyright (C) 1998 Elsevier Science B.V.

KW - Gastric motility

KW - Hepatic

KW - Osmoreceptor

KW - Portal

KW - Stomach

KW - Vagal nerve

UR - http://www.scopus.com/inward/record.url?scp=0031736833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031736833&partnerID=8YFLogxK

U2 - 10.1016/S0165-1838(98)00138-6

DO - 10.1016/S0165-1838(98)00138-6

M3 - Article

VL - 73

SP - 156

EP - 162

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

SN - 1566-0702

IS - 2-3

ER -