FAcile synthesis of pyrano[3,2-e]indoles via the basepromoted pictet-spengler reaction of Nb-benzylserotonin

Koji Yamada; Sayaka Yamaguchi; Noriyuki Hatae; Takumi Abe; Tatsunori Iwamura; Minoru Ishikura

doi:10.3987/COM-11-12144

FAcile synthesis of pyrano[3,2-e]indoles via the basepromoted pictet-spengler reaction of N_b-benzylserotonin

Koji Yamada, Sayaka Yamaguchi, Noriyuki Hatae, Takumi Abe, Tatsunori Iwamura, Minoru Ishikura

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A novel and simple protocol for the synthesis of 1-(2-aminoethyl)- pyrano[3,2-e]indole derivatives has been developed using the Pictet-Spengler reaction of Nb-benzylserotonin with αβ-unsaturated aldehydes in the presence of Et3N in 2-propanol or MeOH.

Original language	English
Pages (from-to)	815-826
Number of pages	12
Journal	Heterocycles
Volume	83
Issue number	4
DOIs	https://doi.org/10.3987/COM-11-12144
Publication status	Published - Mar 28 2011
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "A novel and simple protocol for the synthesis of 1-(2-aminoethyl)- pyrano[3,2-e]indole derivatives has been developed using the Pictet-Spengler reaction of Nb-benzylserotonin with αβ-unsaturated aldehydes in the presence of Et3N in 2-propanol or MeOH.",

author = "Koji Yamada and Sayaka Yamaguchi and Noriyuki Hatae and Takumi Abe and Tatsunori Iwamura and Minoru Ishikura",

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AU - Yamada, Koji

AU - Yamaguchi, Sayaka

AU - Hatae, Noriyuki

AU - Abe, Takumi

AU - Iwamura, Tatsunori

AU - Ishikura, Minoru

PY - 2011/3/28

Y1 - 2011/3/28

N2 - A novel and simple protocol for the synthesis of 1-(2-aminoethyl)- pyrano[3,2-e]indole derivatives has been developed using the Pictet-Spengler reaction of Nb-benzylserotonin with αβ-unsaturated aldehydes in the presence of Et3N in 2-propanol or MeOH.

AB - A novel and simple protocol for the synthesis of 1-(2-aminoethyl)- pyrano[3,2-e]indole derivatives has been developed using the Pictet-Spengler reaction of Nb-benzylserotonin with αβ-unsaturated aldehydes in the presence of Et3N in 2-propanol or MeOH.

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FAcile synthesis of pyrano[3,2-e]indoles via the basepromoted pictet-spengler reaction of N_b-benzylserotonin

Abstract

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