Fabrication of reconfigurable protein matrices by cracking

Xiaoyue Zhu, Kristen L. Mills, Portia R. Peters, Joong Hwan Bahng, Elizabeth Ho Liu, Jeongsup Shim, Keiji Naruse, Marie E. Csete, M. D. Thouless, Shuichi Takayama

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

The fabrication of substrates containing arrays of cracks in which cell-adhesive proteins are selectively adsorbed was described. The widths of the cracks were similar in size to individual adhesion complexes and can be modulated by adjusting the mechanical strain applied to the substrate. It was observed that morphology of cells can be reversibly manipulated multiple times through in situ adjustment of crack widths and hence the amount of the cell-adhesive proteins accessible to the cell. The results show that these substrates provide a new tool for assessing cellular responses associated with exposure to matrix proteins.

Original languageEnglish
Pages (from-to)403-406
Number of pages4
JournalNature Materials
Volume4
Issue number5
DOIs
Publication statusPublished - May 2005
Externally publishedYes

Fingerprint

Cracks
proteins
Proteins
Fabrication
fabrication
cracks
Adhesives
Substrates
matrices
cells
adhesives
adjusting
Adhesion
adhesion

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Zhu, X., Mills, K. L., Peters, P. R., Bahng, J. H., Liu, E. H., Shim, J., ... Takayama, S. (2005). Fabrication of reconfigurable protein matrices by cracking. Nature Materials, 4(5), 403-406. https://doi.org/10.1038/nmat1365

Fabrication of reconfigurable protein matrices by cracking. / Zhu, Xiaoyue; Mills, Kristen L.; Peters, Portia R.; Bahng, Joong Hwan; Liu, Elizabeth Ho; Shim, Jeongsup; Naruse, Keiji; Csete, Marie E.; Thouless, M. D.; Takayama, Shuichi.

In: Nature Materials, Vol. 4, No. 5, 05.2005, p. 403-406.

Research output: Contribution to journalArticle

Zhu, X, Mills, KL, Peters, PR, Bahng, JH, Liu, EH, Shim, J, Naruse, K, Csete, ME, Thouless, MD & Takayama, S 2005, 'Fabrication of reconfigurable protein matrices by cracking', Nature Materials, vol. 4, no. 5, pp. 403-406. https://doi.org/10.1038/nmat1365
Zhu X, Mills KL, Peters PR, Bahng JH, Liu EH, Shim J et al. Fabrication of reconfigurable protein matrices by cracking. Nature Materials. 2005 May;4(5):403-406. https://doi.org/10.1038/nmat1365
Zhu, Xiaoyue ; Mills, Kristen L. ; Peters, Portia R. ; Bahng, Joong Hwan ; Liu, Elizabeth Ho ; Shim, Jeongsup ; Naruse, Keiji ; Csete, Marie E. ; Thouless, M. D. ; Takayama, Shuichi. / Fabrication of reconfigurable protein matrices by cracking. In: Nature Materials. 2005 ; Vol. 4, No. 5. pp. 403-406.
@article{5a1f1971b8b24b4ba0c45feabed14bf5,
title = "Fabrication of reconfigurable protein matrices by cracking",
abstract = "The fabrication of substrates containing arrays of cracks in which cell-adhesive proteins are selectively adsorbed was described. The widths of the cracks were similar in size to individual adhesion complexes and can be modulated by adjusting the mechanical strain applied to the substrate. It was observed that morphology of cells can be reversibly manipulated multiple times through in situ adjustment of crack widths and hence the amount of the cell-adhesive proteins accessible to the cell. The results show that these substrates provide a new tool for assessing cellular responses associated with exposure to matrix proteins.",
author = "Xiaoyue Zhu and Mills, {Kristen L.} and Peters, {Portia R.} and Bahng, {Joong Hwan} and Liu, {Elizabeth Ho} and Jeongsup Shim and Keiji Naruse and Csete, {Marie E.} and Thouless, {M. D.} and Shuichi Takayama",
year = "2005",
month = "5",
doi = "10.1038/nmat1365",
language = "English",
volume = "4",
pages = "403--406",
journal = "Nature Materials",
issn = "1476-1122",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Fabrication of reconfigurable protein matrices by cracking

AU - Zhu, Xiaoyue

AU - Mills, Kristen L.

AU - Peters, Portia R.

AU - Bahng, Joong Hwan

AU - Liu, Elizabeth Ho

AU - Shim, Jeongsup

AU - Naruse, Keiji

AU - Csete, Marie E.

AU - Thouless, M. D.

AU - Takayama, Shuichi

PY - 2005/5

Y1 - 2005/5

N2 - The fabrication of substrates containing arrays of cracks in which cell-adhesive proteins are selectively adsorbed was described. The widths of the cracks were similar in size to individual adhesion complexes and can be modulated by adjusting the mechanical strain applied to the substrate. It was observed that morphology of cells can be reversibly manipulated multiple times through in situ adjustment of crack widths and hence the amount of the cell-adhesive proteins accessible to the cell. The results show that these substrates provide a new tool for assessing cellular responses associated with exposure to matrix proteins.

AB - The fabrication of substrates containing arrays of cracks in which cell-adhesive proteins are selectively adsorbed was described. The widths of the cracks were similar in size to individual adhesion complexes and can be modulated by adjusting the mechanical strain applied to the substrate. It was observed that morphology of cells can be reversibly manipulated multiple times through in situ adjustment of crack widths and hence the amount of the cell-adhesive proteins accessible to the cell. The results show that these substrates provide a new tool for assessing cellular responses associated with exposure to matrix proteins.

UR - http://www.scopus.com/inward/record.url?scp=20244371663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20244371663&partnerID=8YFLogxK

U2 - 10.1038/nmat1365

DO - 10.1038/nmat1365

M3 - Article

VL - 4

SP - 403

EP - 406

JO - Nature Materials

JF - Nature Materials

SN - 1476-1122

IS - 5

ER -