Fabrication of reconfigurable protein matrices by cracking

Xiaoyue Zhu, Kristen L. Mills, Portia R. Peters, Joong Hwan Bahng, Elizabeth Ho Liu, Jeongsup Shim, Keiji Naruse, Marie E. Csete, M. D. Thouless, Shuichi Takayama

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108 Citations (Scopus)

Abstract

The fabrication of substrates containing arrays of cracks in which cell-adhesive proteins are selectively adsorbed was described. The widths of the cracks were similar in size to individual adhesion complexes and can be modulated by adjusting the mechanical strain applied to the substrate. It was observed that morphology of cells can be reversibly manipulated multiple times through in situ adjustment of crack widths and hence the amount of the cell-adhesive proteins accessible to the cell. The results show that these substrates provide a new tool for assessing cellular responses associated with exposure to matrix proteins.

Original languageEnglish
Pages (from-to)403-406
Number of pages4
JournalNature Materials
Volume4
Issue number5
DOIs
Publication statusPublished - May 2005
Externally publishedYes

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ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Zhu, X., Mills, K. L., Peters, P. R., Bahng, J. H., Liu, E. H., Shim, J., Naruse, K., Csete, M. E., Thouless, M. D., & Takayama, S. (2005). Fabrication of reconfigurable protein matrices by cracking. Nature Materials, 4(5), 403-406. https://doi.org/10.1038/nmat1365