Fabrication of novel biodegradable α-tricalcium phosphate cement set by chelating capability of inositol phosphate and its biocompatibility

Toshiisa Konishi, Minori Mizumoto, Michiyo Honda, Yukiko Horiguchi, Kazuya Oribe, Hikaru Morisue, Ken Ishii, Yoshiaki Toyama, Morio Matsumoto, Mamoru Aizawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Biodegradable α-tricalcium phosphate (α-TCP) cement based on the chelate-setting mechanism of inositol phosphate (IP6) was developed. This paper examined the effect of the milling time of α-TCP powder on the material properties of the cement. In addition, biocompatibility of the result cement in vitro using osteoblasts and in vivo using rabbit models will be studied as well. The α-TCP powders were ballmilled using ZrO2 beads in pure water for various durations up to 270 minutes, with a single-phase α-TCP obtained at ballmilling for 120 minutes. The resulting cement was mostly composed of α-TCP phase, and the compressive strength of the cement was 8.5±1.1 MPa, which suggested that the cements set with keeping the crystallite phase of starting cement powder. The cell-culture test indicated that the resulting cements were biocompatible materials. In vivo studies showed that the newly formed bones increased with milling time at a slight distance from the cement specimens and grew mature at 24 weeks, and the surface of the cement was resorbed by tartrate-resistant acid phosphatase-(TRAP-)positive osteoclast-like cells until 24 weeks of implantation. The present α-TCP cement is promising for application as a novel paste-like artificial bone with biodegradability and osteoconductivity.

Original languageEnglish
Article number864374
JournalJournal of Nanomaterials
Volume2013
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Inositol Phosphates
Chelation
Biocompatibility
Cements
Phosphates
Fabrication
Powders
Bone
tricalcium phosphate
Bone cement
Biodegradability
Osteoblasts
Phosphatases
Biocompatible Materials
Ointments
Acid Phosphatase
Cell culture
Biomaterials
Compressive strength
Materials properties

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Fabrication of novel biodegradable α-tricalcium phosphate cement set by chelating capability of inositol phosphate and its biocompatibility. / Konishi, Toshiisa; Mizumoto, Minori; Honda, Michiyo; Horiguchi, Yukiko; Oribe, Kazuya; Morisue, Hikaru; Ishii, Ken; Toyama, Yoshiaki; Matsumoto, Morio; Aizawa, Mamoru.

In: Journal of Nanomaterials, Vol. 2013, 864374, 2013.

Research output: Contribution to journalArticle

Konishi, T, Mizumoto, M, Honda, M, Horiguchi, Y, Oribe, K, Morisue, H, Ishii, K, Toyama, Y, Matsumoto, M & Aizawa, M 2013, 'Fabrication of novel biodegradable α-tricalcium phosphate cement set by chelating capability of inositol phosphate and its biocompatibility', Journal of Nanomaterials, vol. 2013, 864374. https://doi.org/10.1155/2013/864374
Konishi, Toshiisa ; Mizumoto, Minori ; Honda, Michiyo ; Horiguchi, Yukiko ; Oribe, Kazuya ; Morisue, Hikaru ; Ishii, Ken ; Toyama, Yoshiaki ; Matsumoto, Morio ; Aizawa, Mamoru. / Fabrication of novel biodegradable α-tricalcium phosphate cement set by chelating capability of inositol phosphate and its biocompatibility. In: Journal of Nanomaterials. 2013 ; Vol. 2013.
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