Fabrication of medical device from photoreactive particles having tissue-adhesion

Masahiro Okada; Miwa Masuda; Shoji Yasuda; Tsutomu Furuzono

Fabrication of medical device from photoreactive particles having tissue-adhesion

Masahiro Okada, Miwa Masuda, Shoji Yasuda, Tsutomu Furuzono

Research output: Contribution to conference › Paper › peer-review

Abstract

A composite consisting of titanium dioxide (Ti02) particle, the surface of which was modified with amino groups, and a silicone substrate through covalent bonding at their interface was developed, and antibacterial and cell adhesion activities of the composite were evaluated. The density of the amino groups on the Ti02 particle surface was controlled by the reaction time of the modification reaction, and optimized by evaluation of photoreactivity and cell adhesion property of the amino-group-modified TiO ₂ particles. The optimum amino group-modified TiO ₂/silicone composite sheet (amino group density, 3.0 molecules/nm ²) showed an effective antibacterial activity for E. coli bacteria under UV irradiation, whereas the original silicone sheet showed almost no antibacterial activity under the same UV irradiation conditions.

Original language	English
Number of pages	1
Publication status	Published - Oct 19 2006
Externally published	Yes
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: May 24 2006 → May 26 2006

Other

Other	55th SPSJ Annual Meeting
Country	Japan
City	Nagoya
Period	5/24/06 → 5/26/06

Keywords

Composite
Medical device
Photoreactivity
Tissue adhesion
Titanium dioxide

ASJC Scopus subject areas

Engineering(all)

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Cite this

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title = "Fabrication of medical device from photoreactive particles having tissue-adhesion",

abstract = "A composite consisting of titanium dioxide (Ti02) particle, the surface of which was modified with amino groups, and a silicone substrate through covalent bonding at their interface was developed, and antibacterial and cell adhesion activities of the composite were evaluated. The density of the amino groups on the Ti02 particle surface was controlled by the reaction time of the modification reaction, and optimized by evaluation of photoreactivity and cell adhesion property of the amino-group-modified TiO 2 particles. The optimum amino group-modified TiO 2/silicone composite sheet (amino group density, 3.0 molecules/nm 2) showed an effective antibacterial activity for E. coli bacteria under UV irradiation, whereas the original silicone sheet showed almost no antibacterial activity under the same UV irradiation conditions.",

keywords = "Composite, Medical device, Photoreactivity, Tissue adhesion, Titanium dioxide",

author = "Masahiro Okada and Miwa Masuda and Shoji Yasuda and Tsutomu Furuzono",

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T1 - Fabrication of medical device from photoreactive particles having tissue-adhesion

AU - Okada, Masahiro

AU - Masuda, Miwa

AU - Yasuda, Shoji

AU - Furuzono, Tsutomu

PY - 2006/10/19

Y1 - 2006/10/19

N2 - A composite consisting of titanium dioxide (Ti02) particle, the surface of which was modified with amino groups, and a silicone substrate through covalent bonding at their interface was developed, and antibacterial and cell adhesion activities of the composite were evaluated. The density of the amino groups on the Ti02 particle surface was controlled by the reaction time of the modification reaction, and optimized by evaluation of photoreactivity and cell adhesion property of the amino-group-modified TiO 2 particles. The optimum amino group-modified TiO 2/silicone composite sheet (amino group density, 3.0 molecules/nm 2) showed an effective antibacterial activity for E. coli bacteria under UV irradiation, whereas the original silicone sheet showed almost no antibacterial activity under the same UV irradiation conditions.

AB - A composite consisting of titanium dioxide (Ti02) particle, the surface of which was modified with amino groups, and a silicone substrate through covalent bonding at their interface was developed, and antibacterial and cell adhesion activities of the composite were evaluated. The density of the amino groups on the Ti02 particle surface was controlled by the reaction time of the modification reaction, and optimized by evaluation of photoreactivity and cell adhesion property of the amino-group-modified TiO 2 particles. The optimum amino group-modified TiO 2/silicone composite sheet (amino group density, 3.0 molecules/nm 2) showed an effective antibacterial activity for E. coli bacteria under UV irradiation, whereas the original silicone sheet showed almost no antibacterial activity under the same UV irradiation conditions.

KW - Composite

KW - Medical device

KW - Photoreactivity

KW - Tissue adhesion

KW - Titanium dioxide

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