Fabrication of medical device from photoreactive particles having tissue-adhesion

Masahiro Okada, Miwa Masuda, Shoji Yasuda, Tsutomu Furuzono

Research output: Contribution to conferencePaperpeer-review

1 Citation (Scopus)


A composite consisting of titanium dioxide (Ti02) particle, the surface of which was modified with amino groups, and a silicone substrate through covalent bonding at their interface was developed, and antibacterial and cell adhesion activities of the composite were evaluated. The density of the amino groups on the Ti02 particle surface was controlled by the reaction time of the modification reaction, and optimized by evaluation of photoreactivity and cell adhesion property of the amino-group-modified TiO 2 particles. The optimum amino group-modified TiO 2/silicone composite sheet (amino group density, 3.0 molecules/nm 2) showed an effective antibacterial activity for E. coli bacteria under UV irradiation, whereas the original silicone sheet showed almost no antibacterial activity under the same UV irradiation conditions.

Original languageEnglish
Number of pages1
Publication statusPublished - Oct 19 2006
Externally publishedYes
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: May 24 2006May 26 2006


Other55th SPSJ Annual Meeting


  • Composite
  • Medical device
  • Photoreactivity
  • Tissue adhesion
  • Titanium dioxide

ASJC Scopus subject areas

  • Engineering(all)


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