Fabrication of hydroxyapatite with controlled morphology in a micro-reactor

Eiji Fujii, Koji Kawabata, Yoshiaki Nakazaki, Yuji Tanizawa, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A flow-micro-reactor system was employed to fabricate hydroxyapatite (HAp) in order to mimic the interface between calcium and phosphate solutions on a wet chemical procedure. The mixing ratioof calcium nitrate tetrahydrate and diammonium hydrogenphosphate solution was set to the stoichiometric atomic ratio HAp, 1.67, whilepH value of the product suspension was varied from 6.4 to 10.0. The product morphology was changed from nano-sheet type to nano-particle type via nano-rod one, while theirsize was decreased from 100-500 nm to 50 nm. All as-prepared samples, irrespective of pH value of the resultant suspension, consisted of HAp, predominant phase, octacalcium phosphate (OCP), and dicalcium phosphate dihydrate (DCPD) or dicalcium phosphate anhydrate (DCPA). A batch system using the same solutions yielded very similar results, which confirmed that the reactions inthismicro-reactor well reproduced a large-scalemixing system. Calcining sample obtained from pH 6.4 suspension for 2h at lower temperatures (

Original languageEnglish
Pages (from-to)116-119
Number of pages4
JournalNippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
Volume119
Issue number1386
Publication statusPublished - Feb 2011

Fingerprint

Durapatite
Hydroxyapatite
Suspensions
phosphates
Phosphates
reactors
Fabrication
fabrication
calcium
Calcium
products
nitrates
Nitrates
rods
Temperature

Keywords

  • Calcium phosphate
  • Hydroxyapatite
  • Micro-reactor
  • Nano-sheet
  • Spherical particle

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry
  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Fabrication of hydroxyapatite with controlled morphology in a micro-reactor. / Fujii, Eiji; Kawabata, Koji; Nakazaki, Yoshiaki; Tanizawa, Yuji; Shirosaki, Yuki; Hayakawa, Satoshi; Osaka, Akiyoshi.

In: Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan, Vol. 119, No. 1386, 02.2011, p. 116-119.

Research output: Contribution to journalArticle

Fujii, E, Kawabata, K, Nakazaki, Y, Tanizawa, Y, Shirosaki, Y, Hayakawa, S & Osaka, A 2011, 'Fabrication of hydroxyapatite with controlled morphology in a micro-reactor', Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan, vol. 119, no. 1386, pp. 116-119.
Fujii, Eiji ; Kawabata, Koji ; Nakazaki, Yoshiaki ; Tanizawa, Yuji ; Shirosaki, Yuki ; Hayakawa, Satoshi ; Osaka, Akiyoshi. / Fabrication of hydroxyapatite with controlled morphology in a micro-reactor. In: Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan. 2011 ; Vol. 119, No. 1386. pp. 116-119.
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