Fabrication of chelate-setting α-tricalcium phosphate cement using sodium citrate and sodium alginate as mixing solution and its in vivo osteoconductivity

Toshiisa Konishi, Poon Nian Lim, Michiyo Honda, Masaki Nagaya, Hiroshi Nagashima, Eng San Thian, Mamoru Aizawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Moldable and injectable calcium-phosphate cements (CPCs) are material candidates for bone replacement applications. In the present study, we examined the effectiveness of sodium alginate and sodium citrate additives to the liquid phase of CPC, in improving its handling property as well as mechanical strength. The use of these additives enhanced the handling property significantly, in terms of consistency as compared to CPC without additives due to the liquefying effect caused by the adsorption of citrate ions on the cement particles. Sodium alginate and sodium citrate were added to CPC, which was set by the chelate-bonding capability of inositol phosphate, and was composed of mainly α-tricalcium phosphate (α-TCP) phase (>90%). The compressive strength of the CPC containing sodium alginate and sodium citrate was 3.4±0.3 MPa, which was significantly higher than cement without additives. Furthermore, this cement exhibited favorable osteoconductivity and bioresorbability, and remained the α-TCP phase after 4-week implantation in a pig tibiae model. These results suggested that the cement is a potential candidate as a bioresorbable paste-like artificial bone.

Original languageEnglish
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
DOIs
Publication statusAccepted/In press - Jan 1 2017

Fingerprint

Sodium alginate
Calcium phosphate
Cements
Phosphates
Sodium
Fabrication
Cement additives
Bone
Bone cement
Inositol Phosphates
Ointments
Citric Acid
Compressive strength
Strength of materials
tricalcium phosphate
alginic acid
sodium citrate
calcium phosphate
Ions
Adsorption

Keywords

  • Calcium-phosphate cement
  • Citrate
  • Inositol phosphate
  • Osteoconductivity
  • α-tricalcium phosphate

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

Cite this

Fabrication of chelate-setting α-tricalcium phosphate cement using sodium citrate and sodium alginate as mixing solution and its in vivo osteoconductivity. / Konishi, Toshiisa; Lim, Poon Nian; Honda, Michiyo; Nagaya, Masaki; Nagashima, Hiroshi; Thian, Eng San; Aizawa, Mamoru.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, 01.01.2017.

Research output: Contribution to journalArticle

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AU - Nagashima, Hiroshi

AU - Thian, Eng San

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