Fabrication and characterization of chelate-setting β-tricalcium phosphate cements with enhanced bioresorbability

Kohei Nagata, Toshiisa Konishi, Michiyo Honda, Mamoru Aizawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A novel chelate-setting β-tricalcium phosphate (β-TCP) cement with anti-washout properties have been fabricated previously. This cement has been set on the basis of chelating ability of inositol phosphate (IP6). In this study, the ball-milling and surface-modification conditions of starting β-TCP cement powders were optimized in terms of bioresorbability. Starting powders were prepared by simultaneously ball-milling at 300 rpm for 3 h with 1 mm diameter ZrO2 beads and surface-modifying with 40 cm3 of 3000 ppm IP6 solution. The resulting starting powder was consisted of β-TCP single phase, and had high specific surface area of 48.3 m m2·g-1. Cement pastes were prepared by mixing the starting powder and the aqueous solution composed of 2.5 mass% sodium hydrogen phosphate, 1.5 mass% citric acid and 1.0 mass% sodium alginate at a powder/liquid ratio of 1/0.90 [g·cm-3] for 2 min. After setting in pure water for 72 h, compressive strength of the cement specimens was higher than that of human cancellous bone. Dissolution rate of Ca2+ ions was measured by according to Japanese Industrial Standard T 0330-3. The results of Ca2+ ions dissolution rate test demonstrated that the cement specimens derived from the above starting powder were the highest dissolution rate among examined ones. This cement would be expected as bone fillers with high bioresobability.

Original languageEnglish
Title of host publicationMultifunctional Bioceramics for Innovative Therapy
PublisherTrans Tech Publications Ltd
Pages157-161
Number of pages5
Volume720
ISBN (Print)9783038357568
DOIs
Publication statusPublished - 2017
Event28th Annual Meeting of the International Society for Ceramics in Medicine, Bioceramics 2016 - Charlotte, United States
Duration: Oct 18 2016Oct 21 2016

Publication series

NameKey Engineering Materials
Volume720
ISSN (Print)1013-9826

Other

Other28th Annual Meeting of the International Society for Ceramics in Medicine, Bioceramics 2016
CountryUnited States
CityCharlotte
Period10/18/1610/21/16

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Keywords

  • Bioresorbability
  • Calcium-phosphate cement
  • Chelate-setting cement
  • β-tricalcium phosphate

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Nagata, K., Konishi, T., Honda, M., & Aizawa, M. (2017). Fabrication and characterization of chelate-setting β-tricalcium phosphate cements with enhanced bioresorbability. In Multifunctional Bioceramics for Innovative Therapy (Vol. 720, pp. 157-161). (Key Engineering Materials; Vol. 720). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/KEM.720.157