TY - JOUR
T1 - FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion
T2 - Comparison with ferulic acid
AU - Murakami, Akira
AU - Nakamura, Yoshimasa
AU - Koshimizu, Koichi
AU - Takahashi, Daisuke
AU - Matsumoto, Kazuhiro
AU - Hagihara, Kazuma
AU - Taniguchi, Hisaji
AU - Nomura, Eisaku
AU - Hosoda, Asao
AU - Tsuno, Takuo
AU - Maruta, Yuko
AU - Kim, Ha Won
AU - Kawabata, Kyuichi
AU - Ohigashi, Hajime
N1 - Funding Information:
This research was performed with the support of Special Coordination Funds for Promoting Science and Technology (Leading Research Utilizing the Potential of Regional Science and Technology) from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese Government.
PY - 2002/6/28
Y1 - 2002/6/28
N2 - In our previous study, FA15 (2-methyl-1-butyl ferulic acid) was chemically synthesized as a novel ferulic acid (FA) analog, and found to notably suppress phorbol ester-induced Epstein-Barr virus activation and superoxide anion generation in vitro. In this report, we demonstrated that FA15, in contrast to FA, markedly suppressed the combined lipopolysaccharide and interferon-γ-induced protein expressions of inducible nitric oxide synthase and cyclooxygenase-2, and also inhibited the release of tumor necrosis factor-α accompanied by suppression of I-κB degradation in RAW264.7, a murine macrophage cell line. In ICR mouse skin, topical application of FA15 significantly attenuated phorbol ester-triggered hydrogen peroxide production and edema formation as well as papilloma development while that of FA did not. Our results suggest that FA15, derived from natural sources, is a novel chemopreventive agent, both structurally and functionally.
AB - In our previous study, FA15 (2-methyl-1-butyl ferulic acid) was chemically synthesized as a novel ferulic acid (FA) analog, and found to notably suppress phorbol ester-induced Epstein-Barr virus activation and superoxide anion generation in vitro. In this report, we demonstrated that FA15, in contrast to FA, markedly suppressed the combined lipopolysaccharide and interferon-γ-induced protein expressions of inducible nitric oxide synthase and cyclooxygenase-2, and also inhibited the release of tumor necrosis factor-α accompanied by suppression of I-κB degradation in RAW264.7, a murine macrophage cell line. In ICR mouse skin, topical application of FA15 significantly attenuated phorbol ester-triggered hydrogen peroxide production and edema formation as well as papilloma development while that of FA did not. Our results suggest that FA15, derived from natural sources, is a novel chemopreventive agent, both structurally and functionally.
KW - Cyclooxygenase-2
KW - I-κB
KW - Inducible nitric oxide synthase
KW - Oxidative stress
KW - Tumor necrosis factor-α
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U2 - 10.1016/S0304-3835(01)00858-8
DO - 10.1016/S0304-3835(01)00858-8
M3 - Article
C2 - 12175542
AN - SCOPUS:0037189037
SN - 0304-3835
VL - 180
SP - 121
EP - 129
JO - Cancer Letters
JF - Cancer Letters
IS - 2
ER -
