FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: Comparison with ferulic acid

Akira Murakami, Yoshimasa Nakamura, Koichi Koshimizu, Daisuke Takahashi, Kazuhiro Matsumoto, Kazuma Hagihara, Hisaji Taniguchi, Eisaku Nomura, Asao Hosoda, Takuo Tsuno, Yuko Maruta, Ha Won Kim, Kyuichi Kawabata, Hajime Ohigashi

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

In our previous study, FA15 (2-methyl-1-butyl ferulic acid) was chemically synthesized as a novel ferulic acid (FA) analog, and found to notably suppress phorbol ester-induced Epstein-Barr virus activation and superoxide anion generation in vitro. In this report, we demonstrated that FA15, in contrast to FA, markedly suppressed the combined lipopolysaccharide and interferon-γ-induced protein expressions of inducible nitric oxide synthase and cyclooxygenase-2, and also inhibited the release of tumor necrosis factor-α accompanied by suppression of I-κB degradation in RAW264.7, a murine macrophage cell line. In ICR mouse skin, topical application of FA15 significantly attenuated phorbol ester-triggered hydrogen peroxide production and edema formation as well as papilloma development while that of FA did not. Our results suggest that FA15, derived from natural sources, is a novel chemopreventive agent, both structurally and functionally.

Original languageEnglish
Pages (from-to)121-129
Number of pages9
JournalCancer Letters
Volume180
Issue number2
DOIs
Publication statusPublished - Jun 28 2002
Externally publishedYes

Fingerprint

ferulic acid
Phorbol Esters
Skin
Virus Activation
Neoplasms
Inbred ICR Mouse
Papilloma
Nitric Oxide Synthase Type II
Cyclooxygenase 2
Human Herpesvirus 4
Superoxides
Interferons
Hydrogen Peroxide
Lipopolysaccharides
Edema
Tumor Necrosis Factor-alpha
Macrophages
Cell Line
Proteins

Keywords

  • Cyclooxygenase-2
  • I-κB
  • Inducible nitric oxide synthase
  • Oxidative stress
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion : Comparison with ferulic acid. / Murakami, Akira; Nakamura, Yoshimasa; Koshimizu, Koichi; Takahashi, Daisuke; Matsumoto, Kazuhiro; Hagihara, Kazuma; Taniguchi, Hisaji; Nomura, Eisaku; Hosoda, Asao; Tsuno, Takuo; Maruta, Yuko; Kim, Ha Won; Kawabata, Kyuichi; Ohigashi, Hajime.

In: Cancer Letters, Vol. 180, No. 2, 28.06.2002, p. 121-129.

Research output: Contribution to journalArticle

Murakami, A, Nakamura, Y, Koshimizu, K, Takahashi, D, Matsumoto, K, Hagihara, K, Taniguchi, H, Nomura, E, Hosoda, A, Tsuno, T, Maruta, Y, Kim, HW, Kawabata, K & Ohigashi, H 2002, 'FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: Comparison with ferulic acid', Cancer Letters, vol. 180, no. 2, pp. 121-129. https://doi.org/10.1016/S0304-3835(01)00858-8
Murakami, Akira ; Nakamura, Yoshimasa ; Koshimizu, Koichi ; Takahashi, Daisuke ; Matsumoto, Kazuhiro ; Hagihara, Kazuma ; Taniguchi, Hisaji ; Nomura, Eisaku ; Hosoda, Asao ; Tsuno, Takuo ; Maruta, Yuko ; Kim, Ha Won ; Kawabata, Kyuichi ; Ohigashi, Hajime. / FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion : Comparison with ferulic acid. In: Cancer Letters. 2002 ; Vol. 180, No. 2. pp. 121-129.
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