TY - JOUR
T1 - F9 Cells Can be Differentiated toward Two Distinct, Mutually Exclusive Pathways by Retinoic Acid and Sodium Butyrate
T2 - teratocarcinoma/differentiation/retinoic acid/sodium butyrate
AU - Kosaka, Mitsuko
AU - Takeda, Masashi
AU - Matsumoto, Keishi
AU - Nishimune, Yoshitake
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1994/4
Y1 - 1994/4
N2 - Both retinoic acid (RA) and sodium butyrate (NaB) induce differentiation in embryonal carcinoma F9 cells. Phenotypic changes caused by RA are irreversible, whereas those of NaB are rapid and reversible. In this study, we investigated the effects of combinations of these two agents on F9 cell differentiation and showed that RA had no effect on the cells induced to differentiate with NaB and vice versa. Thus, F9 cells are induced to differentiate along two distinct pathways which are mutually exclusive.
AB - Both retinoic acid (RA) and sodium butyrate (NaB) induce differentiation in embryonal carcinoma F9 cells. Phenotypic changes caused by RA are irreversible, whereas those of NaB are rapid and reversible. In this study, we investigated the effects of combinations of these two agents on F9 cell differentiation and showed that RA had no effect on the cells induced to differentiate with NaB and vice versa. Thus, F9 cells are induced to differentiate along two distinct pathways which are mutually exclusive.
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U2 - 10.1111/j.1440-169X.1994.00223.x
DO - 10.1111/j.1440-169X.1994.00223.x
M3 - Article
AN - SCOPUS:0028243470
VL - 36
SP - 223
EP - 230
JO - Development Growth and Differentiation
JF - Development Growth and Differentiation
SN - 0012-1592
IS - 2
ER -