Abstract
Both retinoic acid (RA) and sodium butyrate (NaB) induce differentiation in embryonal carcinoma F9 cells. Phenotypic changes caused by RA are irreversible, whereas those of NaB are rapid and reversible. In this study, we investigated the effects of combinations of these two agents on F9 cell differentiation and showed that RA had no effect on the cells induced to differentiate with NaB and vice versa. Thus, F9 cells are induced to differentiate along two distinct pathways which are mutually exclusive.
| Original language | English |
|---|---|
| Pages (from-to) | 223-230 |
| Number of pages | 8 |
| Journal | Development Growth and Differentiation |
| Volume | 36 |
| Issue number | 2 |
| Publication status | Published - 1994 |
| Externally published | Yes |
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Keywords
- differentiation
- retinoic acid
- sodium butyrate
- teratocarcinoma
ASJC Scopus subject areas
- Cell Biology
- Developmental Biology
- Anatomy
Cite this
F9 cells can be differentiated toward two distinct, mutually exclusive pathways by retinoic acid and sodium butyrate. / Kosaka, Mitsuko; Takeda, M.; Matsumoto, K.; Nishimune, Y.
In: Development Growth and Differentiation, Vol. 36, No. 2, 1994, p. 223-230.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - F9 cells can be differentiated toward two distinct, mutually exclusive pathways by retinoic acid and sodium butyrate
AU - Kosaka, Mitsuko
AU - Takeda, M.
AU - Matsumoto, K.
AU - Nishimune, Y.
PY - 1994
Y1 - 1994
N2 - Both retinoic acid (RA) and sodium butyrate (NaB) induce differentiation in embryonal carcinoma F9 cells. Phenotypic changes caused by RA are irreversible, whereas those of NaB are rapid and reversible. In this study, we investigated the effects of combinations of these two agents on F9 cell differentiation and showed that RA had no effect on the cells induced to differentiate with NaB and vice versa. Thus, F9 cells are induced to differentiate along two distinct pathways which are mutually exclusive.
AB - Both retinoic acid (RA) and sodium butyrate (NaB) induce differentiation in embryonal carcinoma F9 cells. Phenotypic changes caused by RA are irreversible, whereas those of NaB are rapid and reversible. In this study, we investigated the effects of combinations of these two agents on F9 cell differentiation and showed that RA had no effect on the cells induced to differentiate with NaB and vice versa. Thus, F9 cells are induced to differentiate along two distinct pathways which are mutually exclusive.
KW - differentiation
KW - retinoic acid
KW - sodium butyrate
KW - teratocarcinoma
UR - http://www.scopus.com/inward/record.url?scp=0028243470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028243470&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0028243470
VL - 36
SP - 223
EP - 230
JO - Development Growth and Differentiation
JF - Development Growth and Differentiation
SN - 0012-1592
IS - 2
ER -