F9 Cells Can be Differentiated toward Two Distinct, Mutually Exclusive Pathways by Retinoic Acid and Sodium Butyrate: teratocarcinoma/differentiation/retinoic acid/sodium butyrate

Mitsuko Kosaka, Masashi Takeda, Keishi Matsumoto, Yoshitake Nishimune

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Both retinoic acid (RA) and sodium butyrate (NaB) induce differentiation in embryonal carcinoma F9 cells. Phenotypic changes caused by RA are irreversible, whereas those of NaB are rapid and reversible. In this study, we investigated the effects of combinations of these two agents on F9 cell differentiation and showed that RA had no effect on the cells induced to differentiate with NaB and vice versa. Thus, F9 cells are induced to differentiate along two distinct pathways which are mutually exclusive.

Original languageEnglish
Pages (from-to)223-230
Number of pages8
JournalDevelopment, Growth & Differentiation
Volume36
Issue number2
DOIs
Publication statusPublished - Apr 1994

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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