F-18 FDG PET/CT contributes to more accurate detection of lymph nodal metastasis from actively proliferating esophageal squamous cell carcinoma

Shunsuke Tanabe, Yoshio Naomoto, Yasuhiro Shirakawa, Yasuhiro Fujiwara, Kazufumi Sakurama, Kazuhiro Noma, Munenori Takaoka, Tomoki Yamatsuji, Takao Hiraki, Yoshihiro Okumura, Masahiko Mitani, Mitsumasa Kaji, Susumu Kanazawa, Toshiyoshi Fujiwara

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: Evaluating the status of disease progression is critical for planning a therapeutic strategy for esophageal cancer. In this regard, F-18 fluorodeoxyglucose-labeled positron emission tomography (PET) is one of the most useful diagnostic modalities. However, there is room to improve its diagnostic performance, such as distinguishing lymph nodal metastases from false positives. In this study, we examined the diagnostic accuracy of fluorodeoxyglucose PET accompanied by computed tomography imaging (PET/CT) to detect regional lymph nodal metastasis from esophageal squamous cell carcinoma (ESCC). Methods: A total of 102 patients diagnosed as ESCC were subjected to this study. These patients had a preoperative PET/CT examination to evaluate the existence of metastasis. The values of maximum standardized uptake value (SUV max) in primary tumors and in metastasized lymph nodes were measured to analyze their relationship with various clinicopathologic characteristics including the status of tumor cell proliferation, which was assessed by immunohistochemistry for Ki-67. Results: The SUV max of the primary tumor was positively correlated with tumor size and vessel invasion, and was positively related with the SUV max of lymph nodal metastasis, especially in cases of poorly differentiated ESCC. The SUV max of metastasized lymph nodes was higher in larger-sized metastasized lymph nodes, whereas the Ki-labeling index of lymph nodal metastasis was positively related with the SUV max per unit area (SUV max/mm 2). The diagnostic accuracy of PET/CT (87.3%) was higher than that of conventional CT scans (78.4%). Conclusions: The improved diagnostic accuracy of PET/CT can be explained by its ability to detect actively progressive metastasis at an early phase regardless of size.

Original languageEnglish
Pages (from-to)854-859
Number of pages6
JournalClinical Nuclear Medicine
Volume36
Issue number10
DOIs
Publication statusPublished - Oct 2011

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Lymph
Positron-Emission Tomography
Neoplasm Metastasis
Lymph Nodes
Neoplasms
Fluorodeoxyglucose F18
Esophageal Neoplasms
Disease Progression
Esophageal Squamous Cell Carcinoma
Immunohistochemistry
Cell Proliferation

Keywords

  • Esophageal cancer
  • F-18 fluorodeoxy glucose (FDG)
  • Lymph nodal metastasis
  • Positron emission tomography (PET)
  • Proliferation
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

F-18 FDG PET/CT contributes to more accurate detection of lymph nodal metastasis from actively proliferating esophageal squamous cell carcinoma. / Tanabe, Shunsuke; Naomoto, Yoshio; Shirakawa, Yasuhiro; Fujiwara, Yasuhiro; Sakurama, Kazufumi; Noma, Kazuhiro; Takaoka, Munenori; Yamatsuji, Tomoki; Hiraki, Takao; Okumura, Yoshihiro; Mitani, Masahiko; Kaji, Mitsumasa; Kanazawa, Susumu; Fujiwara, Toshiyoshi.

In: Clinical Nuclear Medicine, Vol. 36, No. 10, 10.2011, p. 854-859.

Research output: Contribution to journalArticle

Tanabe, Shunsuke ; Naomoto, Yoshio ; Shirakawa, Yasuhiro ; Fujiwara, Yasuhiro ; Sakurama, Kazufumi ; Noma, Kazuhiro ; Takaoka, Munenori ; Yamatsuji, Tomoki ; Hiraki, Takao ; Okumura, Yoshihiro ; Mitani, Masahiko ; Kaji, Mitsumasa ; Kanazawa, Susumu ; Fujiwara, Toshiyoshi. / F-18 FDG PET/CT contributes to more accurate detection of lymph nodal metastasis from actively proliferating esophageal squamous cell carcinoma. In: Clinical Nuclear Medicine. 2011 ; Vol. 36, No. 10. pp. 854-859.
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AU - Shirakawa, Yasuhiro

AU - Fujiwara, Yasuhiro

AU - Sakurama, Kazufumi

AU - Noma, Kazuhiro

AU - Takaoka, Munenori

AU - Yamatsuji, Tomoki

AU - Hiraki, Takao

AU - Okumura, Yoshihiro

AU - Mitani, Masahiko

AU - Kaji, Mitsumasa

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N2 - Purpose: Evaluating the status of disease progression is critical for planning a therapeutic strategy for esophageal cancer. In this regard, F-18 fluorodeoxyglucose-labeled positron emission tomography (PET) is one of the most useful diagnostic modalities. However, there is room to improve its diagnostic performance, such as distinguishing lymph nodal metastases from false positives. In this study, we examined the diagnostic accuracy of fluorodeoxyglucose PET accompanied by computed tomography imaging (PET/CT) to detect regional lymph nodal metastasis from esophageal squamous cell carcinoma (ESCC). Methods: A total of 102 patients diagnosed as ESCC were subjected to this study. These patients had a preoperative PET/CT examination to evaluate the existence of metastasis. The values of maximum standardized uptake value (SUV max) in primary tumors and in metastasized lymph nodes were measured to analyze their relationship with various clinicopathologic characteristics including the status of tumor cell proliferation, which was assessed by immunohistochemistry for Ki-67. Results: The SUV max of the primary tumor was positively correlated with tumor size and vessel invasion, and was positively related with the SUV max of lymph nodal metastasis, especially in cases of poorly differentiated ESCC. The SUV max of metastasized lymph nodes was higher in larger-sized metastasized lymph nodes, whereas the Ki-labeling index of lymph nodal metastasis was positively related with the SUV max per unit area (SUV max/mm 2). The diagnostic accuracy of PET/CT (87.3%) was higher than that of conventional CT scans (78.4%). Conclusions: The improved diagnostic accuracy of PET/CT can be explained by its ability to detect actively progressive metastasis at an early phase regardless of size.

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KW - Lymph nodal metastasis

KW - Positron emission tomography (PET)

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