TY - JOUR
T1 - Ezetimibe improves postprandial hyperlipemia and its induced endothelial dysfunction
AU - Yunoki, Kei
AU - Nakamura, Kazufumi
AU - Miyoshi, Toru
AU - Enko, Kenki
AU - Kohno, Kunihisa
AU - Morita, Hiroshi
AU - Kusano, Kengo F.
AU - Ito, Hiroshi
PY - 2011/8
Y1 - 2011/8
N2 - Objective: Postprandial hyperlipemia has been shown to impair endothelial function and contribute to the development of atherosclerosis. We investigated the association between postprandial lipid profiles and endothelial function, and we examined the effects of ezetimibe on postprandial hyperlipemia and lipemia-induced endothelial dysfunction. Methods: A randomized prospective trial in which 10. mg/day of ezetimibe was administered to 10 subjects for 4 weeks and not administered to 10 subjects (control group) was performed. Lipid profiles and endothelial function, assessed by brachial artery flow-mediated dilation (FMD) during a fasting state and at 2, 4, 6 and 8. h after an oral cookie loading test, were determined before and after treatment for 4 weeks. Results: In all subjects before treatment, the maximum reduction in postprandial %FMD was significantly correlated with the maximum increases in postprandial triglyceride (TG) (r = -0.499, P< 0.05) and apolipoprotein B-48 (apoB-48) concentrations (r = -0.551, P< 0.05). Ezetimibe treatment for 4 weeks significantly suppressed postprandial elevation in TG (area under the incremental curve, from 1419 ± 594 to 968 ± 321. mg. h/dl, P< 0.05), remnant lipoprotein cholesterol (from 66.9 ± 27.6 to 38.9 ± 15.4. mg. h/dl, P< 0.01) and apoB-48 (from 58.8 ± 27.5 to 36.2 ± 17.0 μg. h/ml, P< 0.05) concentrations, and postprandial endothelial dysfunction assessed by %FMD (maximum reduction in %FMD, from -2.6 ± 1.1% to -1.2 ± 0.8%, P< 0.05), whereas no significant changes were observed in the control group. Conclusion: Postprandial hyperlipemia is closely correlated with transient endothelial dysfunction. Ezetimibe improves postprandial hyperlipemia and its induced endothelial dysfunction.
AB - Objective: Postprandial hyperlipemia has been shown to impair endothelial function and contribute to the development of atherosclerosis. We investigated the association between postprandial lipid profiles and endothelial function, and we examined the effects of ezetimibe on postprandial hyperlipemia and lipemia-induced endothelial dysfunction. Methods: A randomized prospective trial in which 10. mg/day of ezetimibe was administered to 10 subjects for 4 weeks and not administered to 10 subjects (control group) was performed. Lipid profiles and endothelial function, assessed by brachial artery flow-mediated dilation (FMD) during a fasting state and at 2, 4, 6 and 8. h after an oral cookie loading test, were determined before and after treatment for 4 weeks. Results: In all subjects before treatment, the maximum reduction in postprandial %FMD was significantly correlated with the maximum increases in postprandial triglyceride (TG) (r = -0.499, P< 0.05) and apolipoprotein B-48 (apoB-48) concentrations (r = -0.551, P< 0.05). Ezetimibe treatment for 4 weeks significantly suppressed postprandial elevation in TG (area under the incremental curve, from 1419 ± 594 to 968 ± 321. mg. h/dl, P< 0.05), remnant lipoprotein cholesterol (from 66.9 ± 27.6 to 38.9 ± 15.4. mg. h/dl, P< 0.01) and apoB-48 (from 58.8 ± 27.5 to 36.2 ± 17.0 μg. h/ml, P< 0.05) concentrations, and postprandial endothelial dysfunction assessed by %FMD (maximum reduction in %FMD, from -2.6 ± 1.1% to -1.2 ± 0.8%, P< 0.05), whereas no significant changes were observed in the control group. Conclusion: Postprandial hyperlipemia is closely correlated with transient endothelial dysfunction. Ezetimibe improves postprandial hyperlipemia and its induced endothelial dysfunction.
KW - Endothelial function
KW - Ezetimibe
KW - Postprandial hyperlipemia
KW - Triglyceride-rich lipoproteins
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U2 - 10.1016/j.atherosclerosis.2011.04.019
DO - 10.1016/j.atherosclerosis.2011.04.019
M3 - Article
C2 - 21592480
AN - SCOPUS:79960698721
SN - 0021-9150
VL - 217
SP - 486
EP - 491
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -