Extreme tooth abnormalities and treatment under general anesthesia in a child with chronic GVHD surviving relapse of acute lymphoblastic leukemia

Shigeru Maeda, M. Suda, M. Ishii, Y. Tomoyasu, Hitoshi Higuchi, Y. Okazaki, Masahiko Egusa, Takuya Miyawaki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Treatment for acute lymphoblastic leukemia (ALL) mainly consists of chemotherapy, irradiation and bone marrow transplantation. In terms of long-term treatment effects, dental abnormalities and chronic graft-versus host disease (GVHD) are problems. We present a patient surviving relapse of ALL at one year of age. He had extreme dental abnormalities and multiple caries. Most of his permanent teeth were abnormal, and multiple caries were observed. Since he had a strong vomiting reaction to dental treatment, general anesthesia was given. During the general anesthesia, much sputum was aspirated because of chronic GVHD. His dental condition was worse than other cases reported previously. Since the survival rate has increased recently, the dental effects of ALL treatment have become significant. Especially, in patients undergoing total body irradiation at under 2 years of age, it is highly likely that dental problems will occur in the future.

Original languageEnglish
Pages (from-to)199-201
Number of pages3
JournalJournal of Clinical Pediatric Dentistry
Volume37
Issue number2
Publication statusPublished - Dec 1 2012

Fingerprint

Tooth Abnormalities
Graft vs Host Disease
Precursor Cell Lymphoblastic Leukemia-Lymphoma
General Anesthesia
Tooth
Recurrence
Therapeutics
Whole-Body Irradiation
Sputum
Bone Marrow Transplantation
Vomiting
Survival Rate
Drug Therapy

Keywords

  • children
  • General Anesthesia
  • Teeth Abnormality Leukemia Graft vs Host Disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dentistry(all)

Cite this

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abstract = "Treatment for acute lymphoblastic leukemia (ALL) mainly consists of chemotherapy, irradiation and bone marrow transplantation. In terms of long-term treatment effects, dental abnormalities and chronic graft-versus host disease (GVHD) are problems. We present a patient surviving relapse of ALL at one year of age. He had extreme dental abnormalities and multiple caries. Most of his permanent teeth were abnormal, and multiple caries were observed. Since he had a strong vomiting reaction to dental treatment, general anesthesia was given. During the general anesthesia, much sputum was aspirated because of chronic GVHD. His dental condition was worse than other cases reported previously. Since the survival rate has increased recently, the dental effects of ALL treatment have become significant. Especially, in patients undergoing total body irradiation at under 2 years of age, it is highly likely that dental problems will occur in the future.",
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T1 - Extreme tooth abnormalities and treatment under general anesthesia in a child with chronic GVHD surviving relapse of acute lymphoblastic leukemia

AU - Maeda, Shigeru

AU - Suda, M.

AU - Ishii, M.

AU - Tomoyasu, Y.

AU - Higuchi, Hitoshi

AU - Okazaki, Y.

AU - Egusa, Masahiko

AU - Miyawaki, Takuya

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AB - Treatment for acute lymphoblastic leukemia (ALL) mainly consists of chemotherapy, irradiation and bone marrow transplantation. In terms of long-term treatment effects, dental abnormalities and chronic graft-versus host disease (GVHD) are problems. We present a patient surviving relapse of ALL at one year of age. He had extreme dental abnormalities and multiple caries. Most of his permanent teeth were abnormal, and multiple caries were observed. Since he had a strong vomiting reaction to dental treatment, general anesthesia was given. During the general anesthesia, much sputum was aspirated because of chronic GVHD. His dental condition was worse than other cases reported previously. Since the survival rate has increased recently, the dental effects of ALL treatment have become significant. Especially, in patients undergoing total body irradiation at under 2 years of age, it is highly likely that dental problems will occur in the future.

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