Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats

Momoe Iwami, Fatma A. Mahmoud, Takahiko Shiina, Haruko Hirayama, Takeshi Shima, Jun Sugita, Yasutake Shimizu

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Grains of paradise (GP) is a species of the ginger family, Zingiberaceae, extracts of which have a pungent, peppery taste due to an aromatic ketone, 6-paradol. The aim of this study was to explore the thermogenic effects of GP extracts and of 6-paradol. Efferent discharges from sympathetic nerves entering the interscapular brown adipose tissue were recorded. Intragastric injection of a GP extract or 6-paradol enhanced the efferent discharges of the sympathetic nerves in a dose-dependent manner. The enhanced nerve discharges were sustained for as long as 3. h. The rats did not become desensitized to the stimulatory effects these compounds on sympathetic nerve activity. The tissue temperature of brown adipose tissue showed significant increase in rats injected with 6-paradol. These results demonstrate that GP extracts and 6-paradol activate thermogenesis in brown adipose tissue, and may open up new avenues for the regulation of weight loss and weight maintenance.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalAutonomic Neuroscience: Basic and Clinical
Volume161
Issue number1-2
DOIs
Publication statusPublished - Apr 26 2011
Externally publishedYes

Keywords

  • Energy expenditure
  • Obesity
  • Pungent compound
  • Sympathetic nerve
  • Thermogenic activity

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats'. Together they form a unique fingerprint.

Cite this