Extracorporeal shock wave therapy accelerates endochondral ossification and fracture healing in a rat femur delayed-union model

Masato Kobayashi, Ryota Chijimatsu, Hideki Yoshikawa, Kiyoshi Yoshida

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Extracorporeal shock wave therapy (ESWT) has been demonstrated to accelerate bone healing; however, the mechanism underlying ESWT-induced bone regeneration has not been fully elucidated. This study aimed to examine the effects of ESWT and the process of fracture healing. A rat model of femur delayed-union was established by cauterizing the periosteum. ESWT treatment at the fracture site was performed 2 weeks after the operation and the site was radiographically and histologically evaluated at weeks 4, 6, and 8. The bone union rate and radiographic score of the ESWT group were significantly higher than those of the control group at 8 weeks. Histological evaluation revealed enhanced endochondral ossification at the fracture site. The effects of ESWT on ATDC5 cells were examined in vitro. ESWT promoted chondrogenic differentiation without inhibiting the proliferation of ATDC5 cells. ESWT may induce significant bone healing by promoting endochondral ossification at the fracture site.

Original languageEnglish
Pages (from-to)632-637
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume530
Issue number4
DOIs
Publication statusPublished - Oct 1 2020
Externally publishedYes

Keywords

  • Delayed-union model
  • Endochondral ossification
  • Extracorporeal shock wave therapy (ESWT)
  • Fracture healing

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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