Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G

Hideki Sanjo, Masaki Hikida, Yuichi Aiba, Yoshiko Mori, Naoya Hatano, Masato Ogata, Tomohiro Kurosaki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Activation of extracellular signal-regulated protein kinase (ERK) has been implicated in proliferation as well as differentiation in a wide variety of cell types. Using B-cell-specific gene-targeted mice, we report here that in T-cell-dependent immune responses, ERK2 is required to generate efficient immunoglobulin G (IgG) production. In its absence, the proportion of antigen-specific surface IgG1-bearing cells and the subsequent number of IgG1 antibody-secreting cells were decreased, despite apparently unimpaired class switch recombination. Notably, this defect was countered by overespression of the antiapoptotic factor Bcl-2. Together, our results suggest that ERK2 plays a key role in efficient generation of antigen-specific IgG-bearing B cells by promoting their survival.

Original languageEnglish
Pages (from-to)1236-1246
Number of pages11
JournalMolecular and Cellular Biology
Volume27
Issue number4
DOIs
Publication statusPublished - Feb 1 2007
Externally publishedYes

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Mitogen-Activated Protein Kinase 1
Protein Kinases
B-Lymphocytes
Immunoglobulin G
Antigens
Antibody-Producing Cells
Extracellular Signal-Regulated MAP Kinases
Surface Antigens
Genetic Recombination
Cell Count
T-Lymphocytes
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G. / Sanjo, Hideki; Hikida, Masaki; Aiba, Yuichi; Mori, Yoshiko; Hatano, Naoya; Ogata, Masato; Kurosaki, Tomohiro.

In: Molecular and Cellular Biology, Vol. 27, No. 4, 01.02.2007, p. 1236-1246.

Research output: Contribution to journalArticle

Sanjo, Hideki ; Hikida, Masaki ; Aiba, Yuichi ; Mori, Yoshiko ; Hatano, Naoya ; Ogata, Masato ; Kurosaki, Tomohiro. / Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G. In: Molecular and Cellular Biology. 2007 ; Vol. 27, No. 4. pp. 1236-1246.
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