Extracellular calcium causes the release of calcium from intracellular stores in chick osteocytes

Hiroshi Kamioka, Yoshiki Miki, Koji Sumitani, Kahori Tagami, Kunihiro Terai, Kazuo Hosoi, Terushige Kawata

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

We have recently demonstrated that a rise in the extracellular divalent cation concentration induces a rapid elevation of cytosolic calcium in chick osteocytes. Here, we demonstrate that cytosolic calcium elevation that occurs in osteocytes on exposure to elevated extracellular calcium is independent of membrane voltage and is insensitive to modulation by organic calcium channel modulators, namely, BAY K 8644, nicardipine, and nifedipine. However, the calcium elevation was sensitive to modulation by an intracellular calcium antagonist, TMB-8, suggesting that the cytosolic calcium elevation was due to mobilization of this cation from an intracellular store.

Original languageEnglish
Pages (from-to)692-696
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume212
Issue number2
DOIs
Publication statusPublished - Jul 17 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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