External validation of severity scoring systems for acute renal failure using a multinational database

Shigehiko Uchino, Rinaldo Bellomo, Hiroshi Morimatsu, Stanislao Morgera, Miet Schetz, Ian Tan, Catherine Bouman, Ettiene Macedo, Noel Gibney, Ashita Tolwani, Gordon S. Doig, Heleen Oudemans Van Straaten, Claudio Ronco, John A. Kellum

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Objective: Several different severity scoring systems specific to acute renal failure have been proposed. However, most validation studies of these scoring systems were conducted in a single center or in a small number of centers, often the same ones used for their development. Therefore, if is not known whether such severity scoring systems may be widely applied. Design: Prospective clinical investigation. Setting: Intensive care units. Patients: One thousand seven hundred and forty-two intensive care unit patients with acute renal failure who were either treated with renal replacement therapy or fulfilled predefined criteria. Interventions: Demographic and clinical information and outcomes were measured. Measurements and Main Results: Scores for four acute renal failure-specific scoring systems and two general scoring systems (Simplified Acute Physiology Score II and Sequential Organ Failure Assessment) were calculated, and their discrimination and calibration were tested with receiver operating characteristic curves and Hosmer-Lemeshow goodness-of fit-tests. For the receiver operating characteristic curves, blood lactate levels were also used as a reference. All scores had an area under the receiver operating characteristic curve

Original languageEnglish
Pages (from-to)1961-1967
Number of pages7
JournalCritical Care Medicine
Volume33
Issue number9
DOIs
Publication statusPublished - Sep 2005
Externally publishedYes

Fingerprint

Acute Kidney Injury
ROC Curve
Databases
Intensive Care Units
Renal Replacement Therapy
Validation Studies
Calibration
Lactic Acid
Demography

Keywords

  • Acute kidney failure
  • Critical illness
  • Hemodialysis
  • Hemofiltration
  • Renal replacement therapy
  • Severity score

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

External validation of severity scoring systems for acute renal failure using a multinational database. / Uchino, Shigehiko; Bellomo, Rinaldo; Morimatsu, Hiroshi; Morgera, Stanislao; Schetz, Miet; Tan, Ian; Bouman, Catherine; Macedo, Ettiene; Gibney, Noel; Tolwani, Ashita; Doig, Gordon S.; Van Straaten, Heleen Oudemans; Ronco, Claudio; Kellum, John A.

In: Critical Care Medicine, Vol. 33, No. 9, 09.2005, p. 1961-1967.

Research output: Contribution to journalArticle

Uchino, S, Bellomo, R, Morimatsu, H, Morgera, S, Schetz, M, Tan, I, Bouman, C, Macedo, E, Gibney, N, Tolwani, A, Doig, GS, Van Straaten, HO, Ronco, C & Kellum, JA 2005, 'External validation of severity scoring systems for acute renal failure using a multinational database', Critical Care Medicine, vol. 33, no. 9, pp. 1961-1967. https://doi.org/10.1097/01.CCM.0000172279.66229.07
Uchino, Shigehiko ; Bellomo, Rinaldo ; Morimatsu, Hiroshi ; Morgera, Stanislao ; Schetz, Miet ; Tan, Ian ; Bouman, Catherine ; Macedo, Ettiene ; Gibney, Noel ; Tolwani, Ashita ; Doig, Gordon S. ; Van Straaten, Heleen Oudemans ; Ronco, Claudio ; Kellum, John A. / External validation of severity scoring systems for acute renal failure using a multinational database. In: Critical Care Medicine. 2005 ; Vol. 33, No. 9. pp. 1961-1967.
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