@article{c1d43c449e52418986965a6c61435dbd,
title = "exSSSRs (extracellular S100 soil sensor receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis",
abstract = "Within the “seed and soil” theory of organ tropic cancer metastasis is a growing compilation of evidence that S100A8/A9 functions as a soil signal that attracts cancer cells to certain organs, which prove beneficial to their growth. S100A8/A9-sensing receptors including Toll-like receptor 4 (TLR4), advanced glycation end products (RAGE), and also important receptors we recently succeeded in identifying (EMMPRIN, NPTNβ, MCAM, and ALCAM) have the potential to become promising therapeutic targets. In our study, we prepared extracellular regions of these novel molecules and fused them to human IgG2-Fc to extend half-life expectancy, and we evaluated the anti-metastatic effects of the purified decoy proteins on metastatic cancer cells. The purified proteins markedly suppressed S100A8/A9-mediated lung tropic cancer metastasis. We hence expect that our novel biologics may become a prominent medicine to prevent cancer metastasis in clinical settings through cutting the linkage between “seed and soil”.",
keywords = "S100A8/A9, decoy biologics, metastasis",
author = "Rie Kinoshita and Hiroki Sato and Akira Yamauchi and Yuta Takahashi and Yusuke Inoue and Sumardika, {I. Wayan} and Youyi Chen and Nahoko Tomonobu and Kota Araki and Kazuhiko Shien and Shuta Tomida and Hidejiro Torigoe and Kei Namba and Eisuke Kurihara and Yusuke Ogoshi and Hitoshi Murata and Yamamoto, {Ken ichi} and Junichiro Futami and Putranto, {Endy Widya} and Ruma, {I. Made Winarsa} and Hiromasa Yamamoto and Junichi Sou and Toshihiko Hibino and Masahiro Nishibori and Eisaku Kondo and Shinichi Toyooka and Masakiyo Sakaguchi",
note = "Funding Information: Key words: decoy biologics, S100A8/A9, metastasis Abbreviations: AGEs: Advanced Glycation End products; CCR7: C-C chemokine receptor 7; CHO: Chinese hamster ovary; CHO: Chinese hamster ovary; CXCR4: C-X-C chemokine receptor 4; HMGB1: High mobility group box 1; HUVECs: Human umbilical vein endothelial cells; IgG: Immunoglobulin G; NHMECs: Normal human mammary epithelial cells; NMMs: Normal mouse melanocytes; Pla2g2d: Group IID phospholipase A2; RAGE: Receptor for Advanced glycation end products; SPECT: Single photon emission computed tomography; TLR4: Toll-like receptor 4 Additional Supporting Information may be found in the online version of this article. †Toshihiko Hibino has passed away on Jun 1 in 2016. Conflict of interest: The authors declare that they have no conflicts of interest. Grant sponsor: Project for Cancer Research and Therapeutic Evolution (P-CREATE) from the Japan Agency for Medical Research and Development (AMED); Grant numbers: JP17cm0106216; Grant sponsor: Fujii Memorial Medical Science Foundation; Grant sponsor: Kobayashi Foundation for Cancer Research; Grant sponsor: Princess Takamatsu Cancer Research Fund; Grant sponsor: Takeda Science Foundation; Grant sponsor: JSPS KAKENHI; Grant numbers: 17H03577 DOI: 10.1002/ijc.31945 History: Received 26 Apr 2018; Accepted 18 Oct 2018; Online 26 Oct 2018 Correspondence to: Masakiyo Sakaguchi, Ph.D., Department of Cell Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan, E-mail: masa-s@md.okayama-u.ac.jp Funding Information: This research was supported by the Project for Cancer Research and Therapeutic Evolution (P-CREATE) from the Japan Agency for Medical Research and Development (AMED, Grant Number JP17cm0106216) to M.S., JSPS KAKENHI (Grant Number 17H03577) to M.S., Takeda Science Foundation to M.S., Princess Takamatsu Cancer Research Fund to M.S., Kobayashi Foundation for Cancer Research to M.S., and Fujii Memorial Medical Science Foundation to M.S. Publisher Copyright: {\textcopyright} 2018 UICC",
year = "2019",
month = jun,
day = "15",
doi = "10.1002/ijc.31945",
language = "English",
volume = "144",
pages = "3138--3145",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "12",
}