Expression Patterns of Two Fibroblast Growth Factor Receptor Genes during Early Chick Eye Development

Hideyo Ohuchi, Eiki Koyama, Fumio Myokai, Tsutomu Nohno, Fumio Shiraga, Toshihiko Matsuo, Nobuhiko Matsuo, Shigehiko Taniguchi, Sumihare Noji

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The expression patterns of two distinct types of fibroblast growth factor receptor (FGFR) genes. FGFR1 and FGFR2, were compared during early chick eye development. In situ hybridization was performed with riboprobes synthesized from cDNA fragments of FGFRs cloned by the polymeruse chain reaction method. FGFR1 was expressed in the prospective lens, neural retina, pigment epithelium and mandibular mesenchyme. In contrast, FGFR2 was expressed predominantly in the periocular mesenchyme of a 2·5 day-old embryo. In the 5·5-day-old embryo, transcripts of FGFR2 were detected in the prospective corneal epithelium. The results suggest that expression patterns of FGFR1 and FGFR2 are complementary and ligands of each FGFR might be involved differentially in early chick eye development. It is concluded that the action of FGFs on pigment epithelium and lens cells reported so far, probably occurs through FGFR1, and both types of FGFR are involved in head mesenchymal development.

Original languageEnglish
Pages (from-to)649-658
Number of pages10
JournalExperimental Eye Research
Volume58
Issue number6
DOIs
Publication statusPublished - Jun 1994
Externally publishedYes

Fingerprint

Fibroblast Growth Factor Receptors
Mesoderm
Lenses
Embryonic Structures
Epithelium
Genes
Corneal Epithelium
In Situ Hybridization
Retina
Complementary DNA
Head
Ligands

Keywords

  • fibroblast growth factor receptor, in situ hybridization, eye, development, chick

ASJC Scopus subject areas

  • Sensory Systems
  • Ophthalmology

Cite this

Expression Patterns of Two Fibroblast Growth Factor Receptor Genes during Early Chick Eye Development. / Ohuchi, Hideyo; Koyama, Eiki; Myokai, Fumio; Nohno, Tsutomu; Shiraga, Fumio; Matsuo, Toshihiko; Matsuo, Nobuhiko; Taniguchi, Shigehiko; Noji, Sumihare.

In: Experimental Eye Research, Vol. 58, No. 6, 06.1994, p. 649-658.

Research output: Contribution to journalArticle

Ohuchi, Hideyo ; Koyama, Eiki ; Myokai, Fumio ; Nohno, Tsutomu ; Shiraga, Fumio ; Matsuo, Toshihiko ; Matsuo, Nobuhiko ; Taniguchi, Shigehiko ; Noji, Sumihare. / Expression Patterns of Two Fibroblast Growth Factor Receptor Genes during Early Chick Eye Development. In: Experimental Eye Research. 1994 ; Vol. 58, No. 6. pp. 649-658.
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AU - Matsuo, Nobuhiko

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