Expression patterns of the lysophospholipid receptor genes during mouse early development

Hideyo Ohuchi, Aska Hamada, Hironao Matsuda, Akira Takagi, Masayuki Tanaka, Junken Aoki, Hiroyuki Arai, Sumihare Noji

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are known to mediate various biological responses, including cell proliferation, migration, and differentiation. To better understand the role of these lipids in mammalian early development, we applied whole-mount in situ hybridization techniques to E8.5 to E12.5 mouse embryos. We determined the expression patterns of the following LP receptor genes, which belong to the G protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P 1 to S1P5 and LPA1 to LPA3), LPA4 (GPR23 /P2Y9), and LPA5 (GPR92). We found that the S1P/LPA receptor genes exhibit overlapping expression patterns in a variety of organ primordia, including the developing brain and cardiovascular system, presomitic mesoderm and somites, branchial arches, and limb buds. These results suggest that multiple receptor systems for LPA/S1P lysophospholipids may be functioning during organogenesis.

Original languageEnglish
Pages (from-to)3280-3294
Number of pages15
JournalDevelopmental Dynamics
Volume237
Issue number11
DOIs
Publication statusPublished - Nov 2008
Externally publishedYes

Fingerprint

Lysophospholipid Receptors
Lysophosphatidic Acid Receptors
Lysophospholipids
Genes
Overlapping Genes
Branchial Region
Limb Buds
Somites
Organogenesis
Mesoderm
G-Protein-Coupled Receptors
Cardiovascular System
Cell Movement
In Situ Hybridization
Cell Differentiation
Embryonic Structures
Cell Proliferation
Lipids
sphingosine 1-phosphate
Brain

Keywords

  • Edg
  • Endothelial differentiation genes
  • G protein-coupled receptors
  • Gna13
  • GPR23
  • GPR92
  • LPA
  • Lysophosphatidic acid
  • S1P
  • Sphingosine-1-phosphate

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Ohuchi, H., Hamada, A., Matsuda, H., Takagi, A., Tanaka, M., Aoki, J., ... Noji, S. (2008). Expression patterns of the lysophospholipid receptor genes during mouse early development. Developmental Dynamics, 237(11), 3280-3294. https://doi.org/10.1002/dvdy.21736

Expression patterns of the lysophospholipid receptor genes during mouse early development. / Ohuchi, Hideyo; Hamada, Aska; Matsuda, Hironao; Takagi, Akira; Tanaka, Masayuki; Aoki, Junken; Arai, Hiroyuki; Noji, Sumihare.

In: Developmental Dynamics, Vol. 237, No. 11, 11.2008, p. 3280-3294.

Research output: Contribution to journalArticle

Ohuchi, H, Hamada, A, Matsuda, H, Takagi, A, Tanaka, M, Aoki, J, Arai, H & Noji, S 2008, 'Expression patterns of the lysophospholipid receptor genes during mouse early development', Developmental Dynamics, vol. 237, no. 11, pp. 3280-3294. https://doi.org/10.1002/dvdy.21736
Ohuchi, Hideyo ; Hamada, Aska ; Matsuda, Hironao ; Takagi, Akira ; Tanaka, Masayuki ; Aoki, Junken ; Arai, Hiroyuki ; Noji, Sumihare. / Expression patterns of the lysophospholipid receptor genes during mouse early development. In: Developmental Dynamics. 2008 ; Vol. 237, No. 11. pp. 3280-3294.
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