Expression patterns of the activin receptor IIA and IIB genes during chick limb development.

T. Nohno, S. Noji, E. Koyama, F. Myokai, Hideyo Ohuchi, K. Nishikawa, S. Sumitomo, S. Taniguchi, T. Saito

Research output: Contribution to journalArticle

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Abstract

Activin is known to induce axial mesoderm during early development in Xenopus embryo. Activin receptor was recently identified to be a member of transmembrane serine/threonine kinase family. We have studied the role of activin-mediated signaling in the limb morphogenesis by identifying the target cells. We isolated cDNAs encoding chicken activin receptors, cARIIA and cARIIB, and examined their expression patterns during chick embryogenesis. The cARIIA gene is expressed in the apical ectoderm of the limb bud at stage 20-21, whereas the cARIIB gene is expressed uniformly in the limb mesenchyme. Expression of the cARIIA gene is confined to dorsal and ventral mesenchyme at stage 23, and later confined to precartilaginous cells. Transcripts of the cARIIA gene are found in developing neuroepithelium of spinal cord, brain and eye, surface ectoderm differentiating to epidermis, and myoblasts differentiating to muscle. The IIB receptor gene is highly expressed in the developing brain. These results suggest that the activins and their receptors are implicated in the limb development, especially, in differentiation of muscle, skin and bone.

Original languageEnglish
Pages (from-to)705-714
Number of pages10
JournalProgress in Clinical and Biological Research
Volume383 B
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Activin Receptors
Mesoderm
Extremities
Activins
Ectoderm
Genes
Limb Buds
Muscles
Myoblasts
Protein-Serine-Threonine Kinases
Brain
Xenopus
Morphogenesis
Epidermis
Embryonic Development
Chickens
Spinal Cord
Embryonic Structures
Complementary DNA
Gene Expression

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nohno, T., Noji, S., Koyama, E., Myokai, F., Ohuchi, H., Nishikawa, K., ... Saito, T. (1993). Expression patterns of the activin receptor IIA and IIB genes during chick limb development. Progress in Clinical and Biological Research, 383 B, 705-714.

Expression patterns of the activin receptor IIA and IIB genes during chick limb development. / Nohno, T.; Noji, S.; Koyama, E.; Myokai, F.; Ohuchi, Hideyo; Nishikawa, K.; Sumitomo, S.; Taniguchi, S.; Saito, T.

In: Progress in Clinical and Biological Research, Vol. 383 B, 1993, p. 705-714.

Research output: Contribution to journalArticle

Nohno, T, Noji, S, Koyama, E, Myokai, F, Ohuchi, H, Nishikawa, K, Sumitomo, S, Taniguchi, S & Saito, T 1993, 'Expression patterns of the activin receptor IIA and IIB genes during chick limb development.', Progress in Clinical and Biological Research, vol. 383 B, pp. 705-714.
Nohno, T. ; Noji, S. ; Koyama, E. ; Myokai, F. ; Ohuchi, Hideyo ; Nishikawa, K. ; Sumitomo, S. ; Taniguchi, S. ; Saito, T. / Expression patterns of the activin receptor IIA and IIB genes during chick limb development. In: Progress in Clinical and Biological Research. 1993 ; Vol. 383 B. pp. 705-714.
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AU - Nishikawa, K.

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