Expression pattern of REIC/Dkk-3 in mouse squamous epithelia

K. Kataoka, G. Du, N. Maehara, Hitoshi Murata, Masakiyo Sakaguchi, N. Huh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The REIC/Dkk (reduced expression in immortalized cells/Dickkopf-3) gene was originally identified as a tumour-suppressor gene with reduced expression in immortalized cells, cancer-cell lines and tumour tissues. Of the four members of the Dkk family, the REIC/Dkk-3 protein is unique in terms of DNA sequence, expression profiles and biological functions. In this study, we investigated and compared the expression patterns of the REIC/Dkk-3 protein in mouse squamous epithelia. Expression of REIC/Dkk-3 in the back skin was localized to the upper layer of the interfollicular epidermis, and the inner root sheath of hair follicles. Expression of REIC/Dkk-3 was detected in the ear skin, oral mucosa, tongue, oesophagus, uterine cervix, footpad and tail skin, but not in the cornea. Interestingly, expression was localized to the upper layers of these epithelial tissues. The physiological function of REIC/Dkk-3 is still unclear, but our detailed observation highlight its unique expression pattern in squamous epithelia. CED

Original languageEnglish
Pages (from-to)428-431
Number of pages4
JournalClinical and Experimental Dermatology
Volume37
Issue number4
DOIs
Publication statusPublished - Jun 2012

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Epithelium
Skin
Hair Follicle
Mouth Mucosa
Tumor Cell Line
Tumor Suppressor Genes
Tongue
Epidermis
Cervix Uteri
Cornea
Esophagus
Ear
Tail
Proteins
Observation
Genes
Neoplasms

ASJC Scopus subject areas

  • Dermatology

Cite this

Expression pattern of REIC/Dkk-3 in mouse squamous epithelia. / Kataoka, K.; Du, G.; Maehara, N.; Murata, Hitoshi; Sakaguchi, Masakiyo; Huh, N.

In: Clinical and Experimental Dermatology, Vol. 37, No. 4, 06.2012, p. 428-431.

Research output: Contribution to journalArticle

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AU - Huh, N.

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