Expression pattern of acidic and basic fibroblast growth factor genes in adult rat eyes

Sumihare Noji, Toshihiko Matsuo, Eiki Koyama, Tomoichiro Yamaai, Tsutomu Nohno, Nobuhiko Matsuo, Shigehiko Taniguchi

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Although the retinal angiogenic and mitogenic factors have been identified to be acidic and basic fibroblast growth factors (aFGF and bFGF), little information has so far been available about the cells producing them and their function in retinal tissues. We found, by in situ hybridization, that the expression pattern of the aFGF gene differed remarkably from that of the bFGF gene in adult rat eyes. Our results demonstrated that the aFGF gene was produced by photoreceptor visual cells, neuronal cells in the inner nuclear layer and ganglion cells of the retina, in addition to pigment epithelial cells of the choroid, iris and ciliary body, and epithelial cells of the cornea, conjunctiva and lens, while bFGF was synthesized solely by the photoreceptor visual cells.

Original languageEnglish
Pages (from-to)343-349
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume168
Issue number1
DOIs
Publication statusPublished - Apr 16 1990

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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