Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle

Effects of VEGF on prostaglandin production in endometrial cells

Yukari Tasaki, Ryo Nishimura, Masami Shibaya, Hwa Yong Lee, Tomas J. Acosta, Kiyoshi Okuda

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Vascular endothelial growth factor (VEGF) is a well known angiogenic factor that has been suggested to play some physiological roles in reproductive organs. To clarify whether VEGF is involved in regulating bovine endometrial function locally, in experiment 1, we determined the expression of VEGF, VEGF receptor (VEGFR) 1 and VEGFR2 throughout the estrous cycle in endometrial tissues. Endometrial tissue was collected at estrus (Day 0), the early I (Days 2-3), early II (Days 5-6), mid (Days 8-12) and late luteal stages (Days 15-17) and the follicular stage (Days 19-21). RT-PCR and Western blotting analysis revealed that VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P

Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalJournal of Reproduction and Development
Volume56
Issue number2
DOIs
Publication statusPublished - Apr 2010

Fingerprint

vascular endothelial growth factors
endometrium
estrous cycle
prostaglandins
receptors
cattle
corpus luteum
estrus
vascular endothelial growth factor receptor-1
cells
gonads
Western blotting
reverse transcriptase polymerase chain reaction
tissues

Keywords

  • Bovine
  • Endometrium
  • Estrous cycle
  • VEGF
  • VEGF receptors

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle : Effects of VEGF on prostaglandin production in endometrial cells. / Tasaki, Yukari; Nishimura, Ryo; Shibaya, Masami; Lee, Hwa Yong; Acosta, Tomas J.; Okuda, Kiyoshi.

In: Journal of Reproduction and Development, Vol. 56, No. 2, 04.2010, p. 223-229.

Research output: Contribution to journalArticle

Tasaki, Yukari ; Nishimura, Ryo ; Shibaya, Masami ; Lee, Hwa Yong ; Acosta, Tomas J. ; Okuda, Kiyoshi. / Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle : Effects of VEGF on prostaglandin production in endometrial cells. In: Journal of Reproduction and Development. 2010 ; Vol. 56, No. 2. pp. 223-229.
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