Expression of vascular endothelial growth factor-C predicts regional lymph node metastasis in early oral squamous cell carcinoma

Koji Kishimoto, Akira Sasaki, Yasuto Yoshihama, Hiroshi Mese, Goichi Tsukamoto, Tomohiro Matsumura

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The purpose of this study was to investigate the association of the expression of vascular endothelial growth factor-C (VEGF-C) with regional lymph node metastasis in oral squamous cell carcinoma (OSCC). The expression of VEGF-C in biopsy specimens obtained from 62 patients with OSCC was examined by immunohistochemistry. In the early stages of T1 and T2 (38 cases), VEGF-C expression strongly correlated with lymph node metastasis (P<0.001), and the percentage of VEGF-C-positive staining was 88.2% for patients with lymph node metastasis (15 of 17 cases) and 28.6% for those without lymph node metastasis (6 of 21 cases). However, in the advanced stages of T3 and T4, no significant correlation between VEGF-C expression and lymph node metastasis was observed. These results indicate that VEGF-C expression in biopsy specimens can be used as a reliable predictor of regional lymph node metastasis, particularly in early OSCC, and may become an important factor in the selection of appropriate treatment.

Original languageEnglish
Pages (from-to)391-396
Number of pages6
JournalOral Oncology
Volume39
Issue number4
DOIs
Publication statusPublished - Jun 2003

Keywords

  • Oral squamous cell carcinoma
  • Regional lymph node metastasis
  • VEGF-C

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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