Expression of the VLA Family of Integrins in the Renal Glomerulus

Hirofumi Makino, Kenichi Shikata, Shigeru Morioka, Jun Wada, Zensuke Ota

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The expression of glomerular extracellular matrix receptors of the very late antigen (VLA) family was examined in the human renal glomerulus by indirect immunofluorescence studies. β1 subunits of integrin were localized in glomerular epithelial, endothelial and mesangial cells and Bowman's capsule. α 3 integrin was localized dominantly in the glomerular capillary wall and less in the mesangium and Bowman's capsule. α2, α4 and α5 integrins were barely stained in the glomerulus. Our findings indicate that the VLA family of integrins plays an important role in the attachment of glomerular cells to the extracellular matrices.

Original languageEnglish
Pages (from-to)19-21
Number of pages3
Journalthe japanese journal of nephrology
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 1 1993

Keywords

  • extracellular matrix
  • fibronectin receptor
  • glomerulus
  • integrin

ASJC Scopus subject areas

  • Nephrology

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