Abstract
Background: Hepsin is a type II transmembrane serine protease originally identified in the human liver as a cDNA clone. Hepsin was found to be significantly overexpressed in cancer samples compared to matched various tissues (e.g. prostate, renal, ovarian carcinoma). The purpose of the present study was to examine hepsin expression and to evaluate its clinicopathological significance in endometrial cancer. Patients and Methods: Hepsin expression was examined by immunohistochemisty in 34 cases with normal endometrium as a control, 11 cases with endometrial hyperplasia, and 128 cases with endometrioid adenocarcinoma. Results: Hepsin expression was found to be significantly higher in endometrial cancer compared to normal endometrium and endometrial hyperplasia. High levels of hepsin expression were associated with advanced stage (p
| Original language | English |
|---|---|
| Pages (from-to) | 159-164 |
| Number of pages | 6 |
| Journal | Anticancer Research |
| Volume | 28 |
| Issue number | 1 A |
| Publication status | Published - Jan 2008 |
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Keywords
- Endometrial cancer
- Hepsin
- Prognostic significance
ASJC Scopus subject areas
- Cancer Research
- Oncology
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Expression of the serine protease hepsin and clinical outcome of human endometrial cancer. / Matsuo, Tamaki; Nakamura, Keiichiro; Takamoto, Norio; Kodama, Junichi; Hongo, Atsushi; Abrzua, Fernando; Nasu, Yasutomo; Kumon, Hiromi; Hiramatsu, Yuji.
In: Anticancer Research, Vol. 28, No. 1 A, 01.2008, p. 159-164.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of the serine protease hepsin and clinical outcome of human endometrial cancer
AU - Matsuo, Tamaki
AU - Nakamura, Keiichiro
AU - Takamoto, Norio
AU - Kodama, Junichi
AU - Hongo, Atsushi
AU - Abrzua, Fernando
AU - Nasu, Yasutomo
AU - Kumon, Hiromi
AU - Hiramatsu, Yuji
PY - 2008/1
Y1 - 2008/1
N2 - Background: Hepsin is a type II transmembrane serine protease originally identified in the human liver as a cDNA clone. Hepsin was found to be significantly overexpressed in cancer samples compared to matched various tissues (e.g. prostate, renal, ovarian carcinoma). The purpose of the present study was to examine hepsin expression and to evaluate its clinicopathological significance in endometrial cancer. Patients and Methods: Hepsin expression was examined by immunohistochemisty in 34 cases with normal endometrium as a control, 11 cases with endometrial hyperplasia, and 128 cases with endometrioid adenocarcinoma. Results: Hepsin expression was found to be significantly higher in endometrial cancer compared to normal endometrium and endometrial hyperplasia. High levels of hepsin expression were associated with advanced stage (p
AB - Background: Hepsin is a type II transmembrane serine protease originally identified in the human liver as a cDNA clone. Hepsin was found to be significantly overexpressed in cancer samples compared to matched various tissues (e.g. prostate, renal, ovarian carcinoma). The purpose of the present study was to examine hepsin expression and to evaluate its clinicopathological significance in endometrial cancer. Patients and Methods: Hepsin expression was examined by immunohistochemisty in 34 cases with normal endometrium as a control, 11 cases with endometrial hyperplasia, and 128 cases with endometrioid adenocarcinoma. Results: Hepsin expression was found to be significantly higher in endometrial cancer compared to normal endometrium and endometrial hyperplasia. High levels of hepsin expression were associated with advanced stage (p
KW - Endometrial cancer
KW - Hepsin
KW - Prognostic significance
UR - http://www.scopus.com/inward/record.url?scp=40549087264&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40549087264&partnerID=8YFLogxK
M3 - Article
C2 - 18383840
AN - SCOPUS:40549087264
VL - 28
SP - 159
EP - 164
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 1 A
ER -