Expression of the JNK2-α1 gene in the developing chick brain

Tetsuya Ishikawa, Yoko Nakada-Moriya, Chiyo Ando, Nobuya Tanda, Seikoh Nishida, Yosuke Minatogawa, Tsutomu Nohnon

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We have isolated chicken JNK2-α1 encoding a c-Jun N-terminal kinase, and examined the expression during embryogenesis. The kinase domain sequence is well conserved between chicken and mammals, but carboxy-terminal sequence of JNK is divergent from subtype 1 and 2, possibly derived from alternative splicing. The JNK2-α1 gene is preferentially expressed in the neuroepithelium of developing brain at stages 16-26, and transcripts are not detectable in the other region including spinal cord. These results suggest that JNK2-α1 is involved in development of the central nervous system as a mediator of stress-activated protein kinase pathway conferring competence to the external stimuli such as growth factors.

Original languageEnglish
Pages (from-to)489-492
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume234
Issue number2
DOIs
Publication statusPublished - May 19 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Expression of the JNK2-α1 gene in the developing chick brain'. Together they form a unique fingerprint.

Cite this