We have isolated chicken JNK2-α1 encoding a c-Jun N-terminal kinase, and examined the expression during embryogenesis. The kinase domain sequence is well conserved between chicken and mammals, but carboxy-terminal sequence of JNK is divergent from subtype 1 and 2, possibly derived from alternative splicing. The JNK2-α1 gene is preferentially expressed in the neuroepithelium of developing brain at stages 16-26, and transcripts are not detectable in the other region including spinal cord. These results suggest that JNK2-α1 is involved in development of the central nervous system as a mediator of stress-activated protein kinase pathway conferring competence to the external stimuli such as growth factors.
|Number of pages||4|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - May 19 1997|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology