Expression of renin-angiotensin system components in the taste organ of mice

Noriatsu Shigemura, Shingo Takai, Fumie Hirose, Ryusuke Yoshida, Keisuke Sanematsu, Yuzo Ninomiya

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The systemic renin-angiotensin system (RAS) is an important regulator of body fluid and sodium homeostasis. Angiotensin II (AngII) is a key active product of the RAS. We previously revealed that circulating AngII suppresses amiloride-sensitive salt taste responses and enhances the responses to sweet compounds via the AngII type 1 receptor (AT1) expressed in taste cells. However, the molecular mechanisms underlying the modulation of taste function by AngII remain uncharacterized. Here we examined the expression of three RAS components, namely renin, angiotensinogen, and angiotensin-converting enzyme-1 (ACE1), in mouse taste tissues. We found that all three RAS components were present in the taste buds of fungiform and circumvallate papillae and co-expressed with αENaC (epithelial sodium channel α-subunit, a salt taste receptor) or T1R3 (taste receptor type 1 member 3, a sweet taste receptor component). Water-deprived mice exhibited significantly increased levels of renin expression in taste cells (p < 0.05). These results indicate the existence of a local RAS in the taste organ and suggest that taste function may be regulated by both locally-produced and circulating AngII. Such integrated modulation of peripheral taste sensitivity by AngII may play an important role in sodium/calorie homeostasis.

Original languageEnglish
Article number2251
JournalNutrients
Volume11
Issue number9
DOIs
Publication statusPublished - Sep 2019

Keywords

  • Angiotensin II
  • Angiotensin-converting enzyme
  • Angiotensinogen
  • Renin
  • Sodium taste
  • Taste

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Expression of renin-angiotensin system components in the taste organ of mice'. Together they form a unique fingerprint.

  • Cite this

    Shigemura, N., Takai, S., Hirose, F., Yoshida, R., Sanematsu, K., & Ninomiya, Y. (2019). Expression of renin-angiotensin system components in the taste organ of mice. Nutrients, 11(9), [2251]. https://doi.org/10.3390/nu11092251