Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis

Gang Du, Ken Kataoka, Masakiyo Sakaguchi, Fernando Abarzua, Swe Swe Than, Hiroyuki Sonegawa, Teruhiko Makino, Tadamichi Shimizu, Nam Ho Huh

Research output: Contribution to journalArticle

11 Citations (Scopus)


Dickkopf (Dkk) family members are known as Wnt modulators involved in the development, cell growth/differentiation and cancer. REIC/Dkk-3, which does not interfere with Wnt signalling, has been proposed to be a tumor suppressor gene, but its physiological function has remained unclear. In this study, we analysed the expression of REIC/Dkk-3 in normal interfollicular epidermis (IFE) and hyperproliferative epidermis. REIC/Dkk-3 was expressed in human and mouse IFE, being localized at the interface of upper spinous layer and granular layer. Skin cancer cell lines lost REIC/Dkk-3 expression as reported previously. When we analysed patient samples, REIC/Dkk-3 expression was down-regulated in the hyperproliferative epidermis including skin cancers and non-cancerous proliferative diseases. REIC/Dkk-3 expression was also suppressed in the regenerative and inflammative epidermis of model mice. These findings will certainly contribute to the extension of studies on REIC/Dkk-3.

Original languageEnglish
Pages (from-to)273-277
Number of pages5
JournalExperimental Dermatology
Issue number3
Publication statusPublished - Mar 1 2011


  • Hyperproliferative epidermis
  • REIC/Dkk-3
  • Skin cancer
  • TPA
  • Wound healing

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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  • Cite this

    Du, G., Kataoka, K., Sakaguchi, M., Abarzua, F., Than, S. S., Sonegawa, H., Makino, T., Shimizu, T., & Huh, N. H. (2011). Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis. Experimental Dermatology, 20(3), 273-277.