Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion

Takeshi Hayashi, Tatsunori Seki, Keiko Sato, Masanori Iwai, Wen Ri Zhang, Yasuhiro Manabe, Koji Abe

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The highly polysialylated form of neural cell adhesion molecule (PSA-NCAM) is important for neurite outgrowth. With this molecule as a marker of plastic change in neurons, we investigated its temporal expression in rat brain after transient middle cerebral artery (MCA) occlusion. In sham-control brain, only subependymal neurons showed a positive immunoreactivity for PSA-NCAM. After 90 min of transient MCA occlusion, neurons in the piriform cortex began to be positively stained at 1 h, while neurons in the cortex and caudate of the MCA territory became positive after 8 h. The stainings persisted for 1 and 3 days after reperfusion. The present results indicate that neurons in the cerebral cortex and caudate have the capability of plastic change in the adult brain, and that those in the piriform cortex rapidly undergo plastic change probably in response to transneuronal injury.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalBrain Research
Volume907
Issue number1-2
DOIs
Publication statusPublished - Jul 13 2001

Fingerprint

Neural Cell Adhesion Molecules
Middle Cerebral Artery Infarction
Neurons
Brain
Middle Cerebral Artery
Cerebral Cortex
Reperfusion
Staining and Labeling
Wounds and Injuries

Keywords

  • Adhesion molecule
  • Ischemia
  • Plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion. / Hayashi, Takeshi; Seki, Tatsunori; Sato, Keiko; Iwai, Masanori; Ri Zhang, Wen; Manabe, Yasuhiro; Abe, Koji.

In: Brain Research, Vol. 907, No. 1-2, 13.07.2001, p. 130-133.

Research output: Contribution to journalArticle

Hayashi, Takeshi ; Seki, Tatsunori ; Sato, Keiko ; Iwai, Masanori ; Ri Zhang, Wen ; Manabe, Yasuhiro ; Abe, Koji. / Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion. In: Brain Research. 2001 ; Vol. 907, No. 1-2. pp. 130-133.
@article{fc58523a25ea4e6394759e95d9067081,
title = "Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion",
abstract = "The highly polysialylated form of neural cell adhesion molecule (PSA-NCAM) is important for neurite outgrowth. With this molecule as a marker of plastic change in neurons, we investigated its temporal expression in rat brain after transient middle cerebral artery (MCA) occlusion. In sham-control brain, only subependymal neurons showed a positive immunoreactivity for PSA-NCAM. After 90 min of transient MCA occlusion, neurons in the piriform cortex began to be positively stained at 1 h, while neurons in the cortex and caudate of the MCA territory became positive after 8 h. The stainings persisted for 1 and 3 days after reperfusion. The present results indicate that neurons in the cerebral cortex and caudate have the capability of plastic change in the adult brain, and that those in the piriform cortex rapidly undergo plastic change probably in response to transneuronal injury.",
keywords = "Adhesion molecule, Ischemia, Plasticity",
author = "Takeshi Hayashi and Tatsunori Seki and Keiko Sato and Masanori Iwai and {Ri Zhang}, Wen and Yasuhiro Manabe and Koji Abe",
year = "2001",
month = "7",
day = "13",
doi = "10.1016/S0006-8993(01)02543-4",
language = "English",
volume = "907",
pages = "130--133",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion

AU - Hayashi, Takeshi

AU - Seki, Tatsunori

AU - Sato, Keiko

AU - Iwai, Masanori

AU - Ri Zhang, Wen

AU - Manabe, Yasuhiro

AU - Abe, Koji

PY - 2001/7/13

Y1 - 2001/7/13

N2 - The highly polysialylated form of neural cell adhesion molecule (PSA-NCAM) is important for neurite outgrowth. With this molecule as a marker of plastic change in neurons, we investigated its temporal expression in rat brain after transient middle cerebral artery (MCA) occlusion. In sham-control brain, only subependymal neurons showed a positive immunoreactivity for PSA-NCAM. After 90 min of transient MCA occlusion, neurons in the piriform cortex began to be positively stained at 1 h, while neurons in the cortex and caudate of the MCA territory became positive after 8 h. The stainings persisted for 1 and 3 days after reperfusion. The present results indicate that neurons in the cerebral cortex and caudate have the capability of plastic change in the adult brain, and that those in the piriform cortex rapidly undergo plastic change probably in response to transneuronal injury.

AB - The highly polysialylated form of neural cell adhesion molecule (PSA-NCAM) is important for neurite outgrowth. With this molecule as a marker of plastic change in neurons, we investigated its temporal expression in rat brain after transient middle cerebral artery (MCA) occlusion. In sham-control brain, only subependymal neurons showed a positive immunoreactivity for PSA-NCAM. After 90 min of transient MCA occlusion, neurons in the piriform cortex began to be positively stained at 1 h, while neurons in the cortex and caudate of the MCA territory became positive after 8 h. The stainings persisted for 1 and 3 days after reperfusion. The present results indicate that neurons in the cerebral cortex and caudate have the capability of plastic change in the adult brain, and that those in the piriform cortex rapidly undergo plastic change probably in response to transneuronal injury.

KW - Adhesion molecule

KW - Ischemia

KW - Plasticity

UR - http://www.scopus.com/inward/record.url?scp=0035854575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035854575&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(01)02543-4

DO - 10.1016/S0006-8993(01)02543-4

M3 - Article

C2 - 11430894

AN - SCOPUS:0035854575

VL - 907

SP - 130

EP - 133

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -