Expression of podoplanin in the mouse salivary glands

Minoru Hata, Takeshi Ueki, Atsuko Sato, Hiroshi Kojima, Yoshihiko Sawa

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective: Podoplanin is one of the most highly expressed lymphatic-specific genes. Here, we report the distribution of cells expressing podoplanin in mouse salivary glands. Design: We immunohistochemically investigated the distribution of cells expressing podoplanin in mouse major salivary glands by laser-scanning microscopy. The expression of endothelial cell marker PECAM-1 was tested to discriminate lymphatic endothelium from salivary gland cells, and myoepithelial cells were identified by an antibody for P-cadherin. Results: The podoplanin expression was rarely found in acini of the parotid gland but clearly found at the basal portion of acini in the submandibular and sublingual glands. The number of portion reacted with anti-podoplanin is greater in the sublingual gland than in the submandibular gland. The expression was also found at the basal portion of ducts in all major salivary glands. The P-cadherin expression was rarely found in acini of the parotid gland but found in acini of the sublingual gland and on ducts in parotid and sublingual glands, corresponding to the area of podoplanin expression. Conclusions: It was suggested that the acinar and myoepithelial cells in the salivary glands have the ability to express podoplanin, and that the expression may be concerned with the mucous saliva excretion.

Original languageEnglish
Pages (from-to)835-841
Number of pages7
JournalArchives of Oral Biology
Volume53
Issue number9
DOIs
Publication statusPublished - Sep 1 2008
Externally publishedYes

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Keywords

  • Parotid gland
  • Podoplanin
  • Sublingual gland
  • Submandibular gland

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

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