Expression of Notch1 and Math1 in mandibular condyle cartilage in neonatal mice

Takako Shimizu, Hidetsugu Tsujigiwa, Hitoshi Nagatsuka, Norimasa Okafuji, Saburo Kurihara, Noriyuki Nagai, Toshiyuki Kawakami

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


On the basis of the cellular morphological changes in the cartilaginous area, the mandibular condylar cartilage is histopathologically composed of four different cell layers - fibrous, proliferative, maturative, and hypertrophic. Reaction for Notch1 was present in the hypertrophic cells only. However, Math1 was locally distributed in the hypertrophic layer and partially in the proliferative layer. The expression patterns of Notch1 and Math1 were slightly different. These results suggest that the morphogenesis regulation factors of Notch1 and Math1 may play some role in mandibular condylar cartilage. Positive reactions to osteopontin, as a control, were detected in the cytoplasm of all layers, although they varied from published data.

Original languageEnglish
Pages (from-to)993-995
Number of pages3
JournalAngle Orthodontist
Issue number6
Publication statusPublished - Nov 2005


  • Immunohistochemistry
  • Mandibular condylar cartilage
  • Math1
  • Notch1
  • Osteopontin

ASJC Scopus subject areas

  • Orthodontics


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