Abstract
Monocyte chemoattractant protein-1 (MCP-1), purified from glioma cell line (U-105MG) culture fluid, attracts monocytes but not neutrophils. Macrophage accumulation is one of the pathological features of meningioma. To investigate the mechanism of macrophage infiltration into meningioma, the expression and localization of MCP-1 in 16 cases of meningioma were studied using Northern blot analysis and immunohistochemistry. Seven of 16 meningiomas expressed MCP-1 messenger ribonucleic acid and protein, and some degree of macrophage infiltration was seen in all 16 meningiomas. There was a relationship between MCP-1 expression and the degree of macrophage infiltration; MCP-1 was strongly expressed in meningiomas with a high degree of macrophage infiltration. Sometimes the meningioma was accompanied by perifocal edema; a correlation between macrophage infiltration into brain tumors and perifocal edema has already been reported. It was found that the degree of MCP-1 expression is not correlated with the extent of perifocal edema. The authors' findings suggest that MCP-1 plays an important role in macrophage infiltration into meningioma.
| Original language | English |
|---|---|
| Pages (from-to) | 874-878 |
| Number of pages | 5 |
| Journal | Journal of Neurosurgery |
| Volume | 82 |
| Issue number | 5 |
| Publication status | Published - 1995 |
| Externally published | Yes |
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Keywords
- immunohistochemistry
- macrophage infiltration
- meningioma
- monocyte chemoattractant protein-1
- mRNA
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Expression of monocyte chemoattractant protein-1 in meningioma. / Sato, K.; Kuratsu, J. I.; Takeshima, H.; Yoshimura, Teizo; Ushio, Y.
In: Journal of Neurosurgery, Vol. 82, No. 5, 1995, p. 874-878.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of monocyte chemoattractant protein-1 in meningioma
AU - Sato, K.
AU - Kuratsu, J. I.
AU - Takeshima, H.
AU - Yoshimura, Teizo
AU - Ushio, Y.
PY - 1995
Y1 - 1995
N2 - Monocyte chemoattractant protein-1 (MCP-1), purified from glioma cell line (U-105MG) culture fluid, attracts monocytes but not neutrophils. Macrophage accumulation is one of the pathological features of meningioma. To investigate the mechanism of macrophage infiltration into meningioma, the expression and localization of MCP-1 in 16 cases of meningioma were studied using Northern blot analysis and immunohistochemistry. Seven of 16 meningiomas expressed MCP-1 messenger ribonucleic acid and protein, and some degree of macrophage infiltration was seen in all 16 meningiomas. There was a relationship between MCP-1 expression and the degree of macrophage infiltration; MCP-1 was strongly expressed in meningiomas with a high degree of macrophage infiltration. Sometimes the meningioma was accompanied by perifocal edema; a correlation between macrophage infiltration into brain tumors and perifocal edema has already been reported. It was found that the degree of MCP-1 expression is not correlated with the extent of perifocal edema. The authors' findings suggest that MCP-1 plays an important role in macrophage infiltration into meningioma.
AB - Monocyte chemoattractant protein-1 (MCP-1), purified from glioma cell line (U-105MG) culture fluid, attracts monocytes but not neutrophils. Macrophage accumulation is one of the pathological features of meningioma. To investigate the mechanism of macrophage infiltration into meningioma, the expression and localization of MCP-1 in 16 cases of meningioma were studied using Northern blot analysis and immunohistochemistry. Seven of 16 meningiomas expressed MCP-1 messenger ribonucleic acid and protein, and some degree of macrophage infiltration was seen in all 16 meningiomas. There was a relationship between MCP-1 expression and the degree of macrophage infiltration; MCP-1 was strongly expressed in meningiomas with a high degree of macrophage infiltration. Sometimes the meningioma was accompanied by perifocal edema; a correlation between macrophage infiltration into brain tumors and perifocal edema has already been reported. It was found that the degree of MCP-1 expression is not correlated with the extent of perifocal edema. The authors' findings suggest that MCP-1 plays an important role in macrophage infiltration into meningioma.
KW - immunohistochemistry
KW - macrophage infiltration
KW - meningioma
KW - monocyte chemoattractant protein-1
KW - mRNA
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M3 - Article
VL - 82
SP - 874
EP - 878
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
SN - 0022-3085
IS - 5
ER -