Expression of monocyte chemoattractant protein-1 in meningioma

K. Sato, J. I. Kuratsu, H. Takeshima, Teizo Yoshimura, Y. Ushio

Research output: Contribution to journalArticle

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Abstract

Monocyte chemoattractant protein-1 (MCP-1), purified from glioma cell line (U-105MG) culture fluid, attracts monocytes but not neutrophils. Macrophage accumulation is one of the pathological features of meningioma. To investigate the mechanism of macrophage infiltration into meningioma, the expression and localization of MCP-1 in 16 cases of meningioma were studied using Northern blot analysis and immunohistochemistry. Seven of 16 meningiomas expressed MCP-1 messenger ribonucleic acid and protein, and some degree of macrophage infiltration was seen in all 16 meningiomas. There was a relationship between MCP-1 expression and the degree of macrophage infiltration; MCP-1 was strongly expressed in meningiomas with a high degree of macrophage infiltration. Sometimes the meningioma was accompanied by perifocal edema; a correlation between macrophage infiltration into brain tumors and perifocal edema has already been reported. It was found that the degree of MCP-1 expression is not correlated with the extent of perifocal edema. The authors' findings suggest that MCP-1 plays an important role in macrophage infiltration into meningioma.

Original languageEnglish
Pages (from-to)874-878
Number of pages5
JournalJournal of Neurosurgery
Volume82
Issue number5
Publication statusPublished - 1995
Externally publishedYes

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Chemokine CCL2
Meningioma
Macrophages
Edema
Brain Neoplasms
Glioma
Northern Blotting
Monocytes
Neutrophils
Immunohistochemistry
RNA
Cell Line

Keywords

  • immunohistochemistry
  • macrophage infiltration
  • meningioma
  • monocyte chemoattractant protein-1
  • mRNA

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Sato, K., Kuratsu, J. I., Takeshima, H., Yoshimura, T., & Ushio, Y. (1995). Expression of monocyte chemoattractant protein-1 in meningioma. Journal of Neurosurgery, 82(5), 874-878.

Expression of monocyte chemoattractant protein-1 in meningioma. / Sato, K.; Kuratsu, J. I.; Takeshima, H.; Yoshimura, Teizo; Ushio, Y.

In: Journal of Neurosurgery, Vol. 82, No. 5, 1995, p. 874-878.

Research output: Contribution to journalArticle

Sato, K, Kuratsu, JI, Takeshima, H, Yoshimura, T & Ushio, Y 1995, 'Expression of monocyte chemoattractant protein-1 in meningioma', Journal of Neurosurgery, vol. 82, no. 5, pp. 874-878.
Sato, K. ; Kuratsu, J. I. ; Takeshima, H. ; Yoshimura, Teizo ; Ushio, Y. / Expression of monocyte chemoattractant protein-1 in meningioma. In: Journal of Neurosurgery. 1995 ; Vol. 82, No. 5. pp. 874-878.
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