Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy

Makoto Kobayashi, Kazufumi Nakamura, Kengo Fukushima Kusano, Yoichi Nakamura, Keiko Ohta-Ogo, Satoshi Nagase, Satoru Sakuragi, Tohru Ohe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Immunological factors have been involved in the pathogenesis of dilated cardiomyopathy (DCM). The cytotoxic action of macrophages is one of the main factors causing cardiac myocyte damage. Monocyte chemoattractant protein-1 (MCP-1) is a major signal for the accumulation of monocytes/macrophages. We examined whether MCP-1 was expressed in the myocardium of DCM patients and whether the expression level was correlated with the degree of impairment of cardiac function. The expression of MCP-1 in the myocardium was determined by immunohistochemistry in endomyocardial biopsy samples from 13 patients. The expression of MCP-1 was found in all myocardial samples from DCM patients but not in those from control subjects. Positive staining for MCP-1 was distinct in cardiac myocytes, interstitium and infiltrating cells. Semi-quantitative analysis revealed that the expression of MCP-1 was inversely correlated with left ventricular ejection fraction. In conclusion, the expression level of MCP-1 in the myocardium was correlated with the degree of impairment of cardiac function in patients with DCM.

Original languageEnglish
Pages (from-to)427-429
Number of pages3
JournalInternational Journal of Cardiology
Volume126
Issue number3
DOIs
Publication statusPublished - Jun 6 2008

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Chemokine CCL2
Dilated Cardiomyopathy
Myocardium
Cardiac Myocytes
Macrophages
Immunologic Factors
Stroke Volume
Monocytes
Immunohistochemistry
Staining and Labeling
Biopsy

Keywords

  • Cardiomyopathy
  • Immunohistochemistry
  • Monocyte

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy. / Kobayashi, Makoto; Nakamura, Kazufumi; Kusano, Kengo Fukushima; Nakamura, Yoichi; Ohta-Ogo, Keiko; Nagase, Satoshi; Sakuragi, Satoru; Ohe, Tohru.

In: International Journal of Cardiology, Vol. 126, No. 3, 06.06.2008, p. 427-429.

Research output: Contribution to journalArticle

Kobayashi, M, Nakamura, K, Kusano, KF, Nakamura, Y, Ohta-Ogo, K, Nagase, S, Sakuragi, S & Ohe, T 2008, 'Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy', International Journal of Cardiology, vol. 126, no. 3, pp. 427-429. https://doi.org/10.1016/j.ijcard.2007.01.109
Kobayashi, Makoto ; Nakamura, Kazufumi ; Kusano, Kengo Fukushima ; Nakamura, Yoichi ; Ohta-Ogo, Keiko ; Nagase, Satoshi ; Sakuragi, Satoru ; Ohe, Tohru. / Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy. In: International Journal of Cardiology. 2008 ; Vol. 126, No. 3. pp. 427-429.
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