Abstract
Immunological factors have been involved in the pathogenesis of dilated cardiomyopathy (DCM). The cytotoxic action of macrophages is one of the main factors causing cardiac myocyte damage. Monocyte chemoattractant protein-1 (MCP-1) is a major signal for the accumulation of monocytes/macrophages. We examined whether MCP-1 was expressed in the myocardium of DCM patients and whether the expression level was correlated with the degree of impairment of cardiac function. The expression of MCP-1 in the myocardium was determined by immunohistochemistry in endomyocardial biopsy samples from 13 patients. The expression of MCP-1 was found in all myocardial samples from DCM patients but not in those from control subjects. Positive staining for MCP-1 was distinct in cardiac myocytes, interstitium and infiltrating cells. Semi-quantitative analysis revealed that the expression of MCP-1 was inversely correlated with left ventricular ejection fraction. In conclusion, the expression level of MCP-1 in the myocardium was correlated with the degree of impairment of cardiac function in patients with DCM.
| Original language | English |
|---|---|
| Pages (from-to) | 427-429 |
| Number of pages | 3 |
| Journal | International Journal of Cardiology |
| Volume | 126 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 6 2008 |
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Keywords
- Cardiomyopathy
- Immunohistochemistry
- Monocyte
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy. / Kobayashi, Makoto; Nakamura, Kazufumi; Kusano, Kengo Fukushima; Nakamura, Yoichi; Ohta-Ogo, Keiko; Nagase, Satoshi; Sakuragi, Satoru; Ohe, Tohru.
In: International Journal of Cardiology, Vol. 126, No. 3, 06.06.2008, p. 427-429.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy
AU - Kobayashi, Makoto
AU - Nakamura, Kazufumi
AU - Kusano, Kengo Fukushima
AU - Nakamura, Yoichi
AU - Ohta-Ogo, Keiko
AU - Nagase, Satoshi
AU - Sakuragi, Satoru
AU - Ohe, Tohru
PY - 2008/6/6
Y1 - 2008/6/6
N2 - Immunological factors have been involved in the pathogenesis of dilated cardiomyopathy (DCM). The cytotoxic action of macrophages is one of the main factors causing cardiac myocyte damage. Monocyte chemoattractant protein-1 (MCP-1) is a major signal for the accumulation of monocytes/macrophages. We examined whether MCP-1 was expressed in the myocardium of DCM patients and whether the expression level was correlated with the degree of impairment of cardiac function. The expression of MCP-1 in the myocardium was determined by immunohistochemistry in endomyocardial biopsy samples from 13 patients. The expression of MCP-1 was found in all myocardial samples from DCM patients but not in those from control subjects. Positive staining for MCP-1 was distinct in cardiac myocytes, interstitium and infiltrating cells. Semi-quantitative analysis revealed that the expression of MCP-1 was inversely correlated with left ventricular ejection fraction. In conclusion, the expression level of MCP-1 in the myocardium was correlated with the degree of impairment of cardiac function in patients with DCM.
AB - Immunological factors have been involved in the pathogenesis of dilated cardiomyopathy (DCM). The cytotoxic action of macrophages is one of the main factors causing cardiac myocyte damage. Monocyte chemoattractant protein-1 (MCP-1) is a major signal for the accumulation of monocytes/macrophages. We examined whether MCP-1 was expressed in the myocardium of DCM patients and whether the expression level was correlated with the degree of impairment of cardiac function. The expression of MCP-1 in the myocardium was determined by immunohistochemistry in endomyocardial biopsy samples from 13 patients. The expression of MCP-1 was found in all myocardial samples from DCM patients but not in those from control subjects. Positive staining for MCP-1 was distinct in cardiac myocytes, interstitium and infiltrating cells. Semi-quantitative analysis revealed that the expression of MCP-1 was inversely correlated with left ventricular ejection fraction. In conclusion, the expression level of MCP-1 in the myocardium was correlated with the degree of impairment of cardiac function in patients with DCM.
KW - Cardiomyopathy
KW - Immunohistochemistry
KW - Monocyte
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U2 - 10.1016/j.ijcard.2007.01.109
DO - 10.1016/j.ijcard.2007.01.109
M3 - Article
C2 - 17467829
AN - SCOPUS:43049154417
VL - 126
SP - 427
EP - 429
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 3
ER -