Expression of metallothionein-III mRNA and its regulation by levodopa in the basal ganglia of hemi-parkinsonian rats

Ikuko Miyazaki, Chiharu Sogawa, Masato Asanuma, Youichirou Higashi, Ken Ichi Tanaka, Tohru Nakanishi, Norio Ogawa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In the brain, metallothionein (MT)-III exhibits a free radical scavenging activity. Here we examined the expression of MT-III mRNA in the basal ganglia of 6-hydroxydopamine (6-OHDA)-lesioned hemi-parkinsonian rats and its regulation by levodopa. The level of MT-III mRNA was significantly decreased in the striatum of 6-OHDA-lesioned side. Levodopa treatment significantly increased the expression of striatal MT-III mRNA in the non-lesioned side, but showed no significant effect in the 6-OHDA-lesioned side. These results suggest that the regulation of MT-III mRNA may be related to the progressive degeneration in parkinsonism. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalNeuroscience Letters
Volume293
Issue number1
DOIs
Publication statusPublished - Oct 20 2000

Fingerprint

Levodopa
Basal Ganglia
Oxidopamine
Messenger RNA
Corpus Striatum
Parkinsonian Disorders
Free Radicals
growth inhibitory factor
Brain

Keywords

  • Growth inhibitory factor
  • Hemi-parkinsonism
  • Levodopa
  • Metallothionein-III
  • Oxidative stress
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Expression of metallothionein-III mRNA and its regulation by levodopa in the basal ganglia of hemi-parkinsonian rats. / Miyazaki, Ikuko; Sogawa, Chiharu; Asanuma, Masato; Higashi, Youichirou; Tanaka, Ken Ichi; Nakanishi, Tohru; Ogawa, Norio.

In: Neuroscience Letters, Vol. 293, No. 1, 20.10.2000, p. 65-68.

Research output: Contribution to journalArticle

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