Expression of interleukin-8 in human glomerulonephritis

Takashi Sekikawa, Naoki Kashihara, Keisuke Maruyama, Minoru Satoh, Kazunori Okamoto, Koichiro Kanao, Yohei Maeshima, Hitoshi Sugiyama, Yasushi Yamasaki, Hirofumi Makino

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Abstract

Interleukin-8 (IL-8) is a cytokine, which possesses both chemotactic and activating properties for neutrophils, lymphocytes and basophils. Various evidence has indicated IL-8 to be implicated in the pathophysiology of immune-mediated renal diseases. We thus examined the expression of IL-8 in renal diseases. We detected the expression of IL-8 both in mRNA and the protein levels in renal biopsy specimens obtained from patients with IgA nephropathy and lupus nephritis. A significant correlation was found between the expression of IL-8 mRNA and the number of neutrophils in the glomerulus. We also found a negative correlation between the expression of IL-8 mRNA and creatinine clearance. Our study thus suggested IL-8 to be involved in the pathophysiology of proliferative glomerulonephritis.

Original languageEnglish
Pages (from-to)217-224
Number of pages8
JournalResearch Communications in Molecular Pathology and Pharmacology
Volume99
Issue number2
Publication statusPublished - Feb 1 1998

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Sekikawa, T., Kashihara, N., Maruyama, K., Satoh, M., Okamoto, K., Kanao, K., Maeshima, Y., Sugiyama, H., Yamasaki, Y., & Makino, H. (1998). Expression of interleukin-8 in human glomerulonephritis. Research Communications in Molecular Pathology and Pharmacology, 99(2), 217-224.