Expression of inflammatory mediators in the otitis media induced by Helicobacter pylori antigen in mice

S. Kariya, Mitsuhiro Okano, K. Fukushima, S. Nomiya, Y. Kataoka, R. Nomiya, H. Akagi, Kazunori Nishizaki

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Helicobacter pylori is a Gram-negative bacterium that is recognized as one of the key factors in gastric diseases such as gastritis, peptic ulcer and gastric cancer. Recent studies have shown relationships between H. pylori and extra-digestive diseases, and the presence of H. pylori in the middle ear and upper respiratory tract has been reported. However, the role of H. pylori in middle ear disease remains unclear. The present study demonstrated that H. pylori whole-cell protein directly induces macrophage migration inhibitory factor, macrophage inflammatory protein 2, interleukin 1β and tumor necrosis factor α in middle ear epithelium in mice, and severe proliferation of inflammatory cells was observed in middle ear cavity inoculated with H. pylori whole-cell protein. In addition, trans-tympanic injection of macrophage migration inhibitory factor up-regulated expression of macrophage inflammatory protein 2 in the middle ear. These findings indicate that H. pylori infection causes immunological inflammation in middle ear epithelium, and H. pylori may play a significant role in otitis media.

Original languageEnglish
Pages (from-to)134-140
Number of pages7
JournalClinical and Experimental Immunology
Issue number1
Publication statusPublished - Oct 2008


  • Cytokine
  • Helicobacter pylori
  • Macrophage inflammatory protein 2
  • Macrophage migration inhibitory factor
  • Otitis media

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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