Abstract
Objective: The objective of this study was to assess the expression of regulatory cytokines and T helper cell (Th)1/Th2 cytokines in paranasal sinus mucoceles. Materials and methods: Fluid samples of 12 paranasal sinus mucoceles were assessed by enzyme-linked immunosorbent assay for concentrations of regulatory cytokines (interleukin [IL]-10 and IL-12), Th1 cytokines (IL-2 and interferon gamma), and Th2 cytokines (IL-4 and IL-5). Results: IL-12 was detected in all samples, whereas IL-10 was detected in only one case. The concentration of IL-12 tended to correlate with that of interferon gamma and was significantly and positively correlated with that of IL-2. Conclusions: Th1 cytokines and the Th1 regulatory cytokine IL-12, but not IL-10, potentially play a key role in the pathogenesis of paranasal sinus mucoceles. Together with our recent report showing that lipopolysaccharide is highly detected in mucocele fluid, the data from this study suggest that the Th1 response induced by lipopolysaccharide may affect the immunological inflammation in the epithelium of paranasal sinus mucoceles.
| Original language | English |
|---|---|
| Pages (from-to) | 83-86 |
| Number of pages | 4 |
| Journal | American Journal of Otolaryngology - Head and Neck Medicine and Surgery |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 2007 |
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ASJC Scopus subject areas
- Otorhinolaryngology
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Expression of IL-12 and T helper cell 1 cytokines in the fluid of paranasal sinus mucoceles. / Kariya, Shin; Okano, Mitsuhiro; Hattori, Hisashi; Sugata, Yuji; Matsumoto, Rie; Fukushima, Kunihiro; Akagi, Hirofumi; Nishizaki, Kazunori.
In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery, Vol. 28, No. 2, 03.2007, p. 83-86.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of IL-12 and T helper cell 1 cytokines in the fluid of paranasal sinus mucoceles
AU - Kariya, Shin
AU - Okano, Mitsuhiro
AU - Hattori, Hisashi
AU - Sugata, Yuji
AU - Matsumoto, Rie
AU - Fukushima, Kunihiro
AU - Akagi, Hirofumi
AU - Nishizaki, Kazunori
PY - 2007/3
Y1 - 2007/3
N2 - Objective: The objective of this study was to assess the expression of regulatory cytokines and T helper cell (Th)1/Th2 cytokines in paranasal sinus mucoceles. Materials and methods: Fluid samples of 12 paranasal sinus mucoceles were assessed by enzyme-linked immunosorbent assay for concentrations of regulatory cytokines (interleukin [IL]-10 and IL-12), Th1 cytokines (IL-2 and interferon gamma), and Th2 cytokines (IL-4 and IL-5). Results: IL-12 was detected in all samples, whereas IL-10 was detected in only one case. The concentration of IL-12 tended to correlate with that of interferon gamma and was significantly and positively correlated with that of IL-2. Conclusions: Th1 cytokines and the Th1 regulatory cytokine IL-12, but not IL-10, potentially play a key role in the pathogenesis of paranasal sinus mucoceles. Together with our recent report showing that lipopolysaccharide is highly detected in mucocele fluid, the data from this study suggest that the Th1 response induced by lipopolysaccharide may affect the immunological inflammation in the epithelium of paranasal sinus mucoceles.
AB - Objective: The objective of this study was to assess the expression of regulatory cytokines and T helper cell (Th)1/Th2 cytokines in paranasal sinus mucoceles. Materials and methods: Fluid samples of 12 paranasal sinus mucoceles were assessed by enzyme-linked immunosorbent assay for concentrations of regulatory cytokines (interleukin [IL]-10 and IL-12), Th1 cytokines (IL-2 and interferon gamma), and Th2 cytokines (IL-4 and IL-5). Results: IL-12 was detected in all samples, whereas IL-10 was detected in only one case. The concentration of IL-12 tended to correlate with that of interferon gamma and was significantly and positively correlated with that of IL-2. Conclusions: Th1 cytokines and the Th1 regulatory cytokine IL-12, but not IL-10, potentially play a key role in the pathogenesis of paranasal sinus mucoceles. Together with our recent report showing that lipopolysaccharide is highly detected in mucocele fluid, the data from this study suggest that the Th1 response induced by lipopolysaccharide may affect the immunological inflammation in the epithelium of paranasal sinus mucoceles.
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UR - http://www.scopus.com/inward/citedby.url?scp=33847745771&partnerID=8YFLogxK
U2 - 10.1016/j.amjoto.2006.06.017
DO - 10.1016/j.amjoto.2006.06.017
M3 - Article
C2 - 17362811
AN - SCOPUS:33847745771
VL - 28
SP - 83
EP - 86
JO - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
JF - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
SN - 0196-0709
IS - 2
ER -