Expression of IL-12 and T helper cell 1 cytokines in the fluid of paranasal sinus mucoceles

Shin Kariya, Mitsuhiro Okano, Hisashi Hattori, Yuji Sugata, Rie Matsumoto, Kunihiro Fukushima, Hirofumi Akagi, Kazunori Nishizaki

Research output: Contribution to journalArticle

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Abstract

Objective: The objective of this study was to assess the expression of regulatory cytokines and T helper cell (Th)1/Th2 cytokines in paranasal sinus mucoceles. Materials and methods: Fluid samples of 12 paranasal sinus mucoceles were assessed by enzyme-linked immunosorbent assay for concentrations of regulatory cytokines (interleukin [IL]-10 and IL-12), Th1 cytokines (IL-2 and interferon gamma), and Th2 cytokines (IL-4 and IL-5). Results: IL-12 was detected in all samples, whereas IL-10 was detected in only one case. The concentration of IL-12 tended to correlate with that of interferon gamma and was significantly and positively correlated with that of IL-2. Conclusions: Th1 cytokines and the Th1 regulatory cytokine IL-12, but not IL-10, potentially play a key role in the pathogenesis of paranasal sinus mucoceles. Together with our recent report showing that lipopolysaccharide is highly detected in mucocele fluid, the data from this study suggest that the Th1 response induced by lipopolysaccharide may affect the immunological inflammation in the epithelium of paranasal sinus mucoceles.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume28
Issue number2
DOIs
Publication statusPublished - Mar 2007

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Mucocele
Th1 Cells
Paranasal Sinuses
Interleukin-12
Cytokines
Interleukin-10
Interferon-gamma
Interleukin-2
Lipopolysaccharides
Interleukin-5
Interleukin-4
Epithelium
Enzyme-Linked Immunosorbent Assay
Inflammation

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Expression of IL-12 and T helper cell 1 cytokines in the fluid of paranasal sinus mucoceles. / Kariya, Shin; Okano, Mitsuhiro; Hattori, Hisashi; Sugata, Yuji; Matsumoto, Rie; Fukushima, Kunihiro; Akagi, Hirofumi; Nishizaki, Kazunori.

In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery, Vol. 28, No. 2, 03.2007, p. 83-86.

Research output: Contribution to journalArticle

Kariya, Shin ; Okano, Mitsuhiro ; Hattori, Hisashi ; Sugata, Yuji ; Matsumoto, Rie ; Fukushima, Kunihiro ; Akagi, Hirofumi ; Nishizaki, Kazunori. / Expression of IL-12 and T helper cell 1 cytokines in the fluid of paranasal sinus mucoceles. In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 2007 ; Vol. 28, No. 2. pp. 83-86.
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AU - Akagi, Hirofumi

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