Expression of highly polysialylated neural cell adhesion molecule in rat subventricular zone with exposure to repeated kindled seizures

K. Sato, M. Iwai, I. Nagano, M. Shoji, K. Abe

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Immunoreactive highly polysialylated neural cell adhesion molecule (PSA-NCAM) expression was examined in the rat with repeated exposure to amygdaloid kindled generalized seizures (GS). In the sham control brain, PSA-NCAM staining was slightly observed in the subventricular zone (SVZ) of the striatum. The number of PSA-NCAM positive cells increased four times in the bilateral SVZ after three consecutive GS, with a further increase after 30 consecutive GS. As PSA-NCAM is involved in neural plasticity as well as migration of neural stem cells (NSC), expression of PSA-NCAM in the SVZ suggests that the recurrent GS may mainly contribute to reconstruction of synaptic network and could also contribute to NSC migration after kindling.

Original languageEnglish
Pages (from-to)244-246
Number of pages3
JournalNeuroscience Letters
Volume323
Issue number3
DOIs
Publication statusPublished - May 3 2002

Keywords

  • Epilepsy
  • Highly polysialylated neural cell adhesion molecule
  • Kindling
  • Neurogenesis
  • Subventricular zone

ASJC Scopus subject areas

  • Neuroscience(all)

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